Concise palladium-catalyzed synthesis of dibenzodiazepines and structural analogues

Dmitry Tsvelikhovsky; Stephen L. Buchwald

doi:10.1021/ja206229y

Concise palladium-catalyzed synthesis of dibenzodiazepines and structural analogues

Dmitry Tsvelikhovsky
, Stephen L. Buchwald

Research output: Contribution to journal › Article › peer-review

Abstract

A general and highly efficient protocol for the synthesis of dibenzodiazepines and their structural analogues is reported. In the presence of catalytic quantities of palladium, readily accessible precursors are cross-coupled with ammonia and then spontaneously undergo an intramolecular condensation to form the corresponding dibenzodiazepines in one step. This new strategy is applicable to the construction of a wide variety of dibenzooxazepines and other structurally related heterocycles.

Original language	English
Pages (from-to)	14228-14231
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	133
Issue number	36
DOIs	https://doi.org/10.1021/ja206229y
State	Published - 14 Sep 2011
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja206229y

Cite this

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title = "Concise palladium-catalyzed synthesis of dibenzodiazepines and structural analogues",

abstract = "A general and highly efficient protocol for the synthesis of dibenzodiazepines and their structural analogues is reported. In the presence of catalytic quantities of palladium, readily accessible precursors are cross-coupled with ammonia and then spontaneously undergo an intramolecular condensation to form the corresponding dibenzodiazepines in one step. This new strategy is applicable to the construction of a wide variety of dibenzooxazepines and other structurally related heterocycles.",

author = "Dmitry Tsvelikhovsky and Buchwald, \{Stephen L.\}",

year = "2011",

month = sep,

day = "14",

doi = "10.1021/ja206229y",

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T1 - Concise palladium-catalyzed synthesis of dibenzodiazepines and structural analogues

AU - Tsvelikhovsky, Dmitry

AU - Buchwald, Stephen L.

PY - 2011/9/14

Y1 - 2011/9/14

N2 - A general and highly efficient protocol for the synthesis of dibenzodiazepines and their structural analogues is reported. In the presence of catalytic quantities of palladium, readily accessible precursors are cross-coupled with ammonia and then spontaneously undergo an intramolecular condensation to form the corresponding dibenzodiazepines in one step. This new strategy is applicable to the construction of a wide variety of dibenzooxazepines and other structurally related heterocycles.

AB - A general and highly efficient protocol for the synthesis of dibenzodiazepines and their structural analogues is reported. In the presence of catalytic quantities of palladium, readily accessible precursors are cross-coupled with ammonia and then spontaneously undergo an intramolecular condensation to form the corresponding dibenzodiazepines in one step. This new strategy is applicable to the construction of a wide variety of dibenzooxazepines and other structurally related heterocycles.

UR - https://www.scopus.com/pages/publications/80052559866

U2 - 10.1021/ja206229y

DO - 10.1021/ja206229y

M3 - مقالة

C2 - 21838278

SN - 0002-7863

VL - 133

SP - 14228

EP - 14231

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 36

ER -

Concise palladium-catalyzed synthesis of dibenzodiazepines and structural analogues

Abstract

ASJC Scopus subject areas

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