Computerized morphometry as an aid in distinguishing recurrent versus nonrecurrent meningiomas

Shawna Noy, Euvgeni Vlodavsky, Geula Klorin, Karen Drumea, Ofer Ben Izhak, Eli Shor, Edmond Sabo

Research output: Contribution to journalArticlepeer-review


OBJECTIVE: To use novel digital and morphometric methods to identify variables able to better predict the recurrence of intracranial meningiomas. STUDY DESIGN: Histologic images from 30 previously diagnosed meningioma tumors that recurred over 10 years of follow-up were consecutively selected from the Rambam Pathology Archives. Images were captured and morphometrically analyzed. Novel algorithms of digital pattern recognition using Fourier transformation and fractal and nuclear texture analyses were applied to evaluate the overall growth pattern complexity of the tumors, as well as the chromatin texture of individual tumor nuclei. The extracted parameters were then correlated with patient prognosis. RESULTS: Kaplan-Meier analyses revealed statistically significant associations between tumor morphometric parameters and recurrence times. Tumors with less nuclear orientation, more nuclear density, higher fractal dimension, and less regular chromatin textures tended to recur faster than those with a higher degree of nuclear order, less pattern complexity, lower density, and more homogeneous chromatin nuclear textures (p < 0.01). CONCLUSION: To our knowledge, these digital morphometric methods were used for the first time to accurately predict tumor recurrence in patients with intracranial meningiomas. The use of these methods may bring additional valuable information to the clinician regarding the optimal management of these patients.

Original languageAmerican English
Pages (from-to)141-150
Number of pages10
JournalAnalytical and Quantitative Cytology and Histology
Issue number3
StatePublished - Jun 2011


  • Computerized morphometry
  • Meningiomas
  • Recurrence

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Histology


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