Computer-Aided Design and Synthesis of 1-{4-[(3,4-Dihydroxybenzylidene)amino]phenyl}-5-oxopyrrolidine-3-carboxylic Acid as an Nrf2 Enhancer

Shirin Kahremany; Ilana Babaev; Pinhas Hasin; Tigist Y. Tamir; Tali Ben-Zur; Guy Cohen; Zhengyu Jiang; Sagiv Weintraub; Daniel Offen; Shai Rahimipour; M. Ben Major; Hanoch Senderowitz; Arie Gruzman

doi:10.1002/cplu.201800155

Computer-Aided Design and Synthesis of 1-{4-[(3,4-Dihydroxybenzylidene)amino]phenyl}-5-oxopyrrolidine-3-carboxylic Acid as an Nrf2 Enhancer

Shirin Kahremany, Ilana Babaev, Pinhas Hasin, Tigist Y. Tamir, Tali Ben-Zur, Guy Cohen, Zhengyu Jiang, Sagiv Weintraub, Daniel Offen, Shai Rahimipour, M. Ben Major, Hanoch Senderowitz, Arie Gruzman

Bar-Ilan University, Tel Aviv University

Research output: Contribution to journal › Comment/debate

Abstract

Invited for this month's cover is Prof. Arie Gruzman (Bar-Ilan University) and collaborators who have developed an Nrf2 enhancer. This compound activated the Nrf2 transduction pathway and because of this the translation of dozens of antioxidant cytoprotective proteins in a dose- and time-dependent manner and protected PC-12 cells against oxidative stress. Considering the imbalance between production and elimination of oxidative species involved in the pathophysiology of many human diseases, this compound is a promising starting point for the development of novel therapeutics for the treatment of oxidative-stress-related diseases. Read the full text of the article at 10.1002/cplu.201700539.

Original language	English
Pages (from-to)	318
Number of pages	1
Journal	ChemPlusChem
Volume	83
Issue number	5
DOIs	https://doi.org/10.1002/cplu.201800155
State	Published - May 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

General Chemistry

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10.1002/cplu.201800155

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Kahremany, S., Babaev, I., Hasin, P., Tamir, T. Y., Ben-Zur, T., Cohen, G., Jiang, Z., Weintraub, S., Offen, D., Rahimipour, S., Major, M. B., Senderowitz, H., & Gruzman, A. (2018). Computer-Aided Design and Synthesis of 1-{4-[(3,4-Dihydroxybenzylidene)amino]phenyl}-5-oxopyrrolidine-3-carboxylic Acid as an Nrf2 Enhancer. ChemPlusChem, 83(5), 318. https://doi.org/10.1002/cplu.201800155

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title = "Computer-Aided Design and Synthesis of 1-\{4-[(3,4-Dihydroxybenzylidene)amino]phenyl\}-5-oxopyrrolidine-3-carboxylic Acid as an Nrf2 Enhancer",

abstract = "Invited for this month's cover is Prof. Arie Gruzman (Bar-Ilan University) and collaborators who have developed an Nrf2 enhancer. This compound activated the Nrf2 transduction pathway and because of this the translation of dozens of antioxidant cytoprotective proteins in a dose- and time-dependent manner and protected PC-12 cells against oxidative stress. Considering the imbalance between production and elimination of oxidative species involved in the pathophysiology of many human diseases, this compound is a promising starting point for the development of novel therapeutics for the treatment of oxidative-stress-related diseases. Read the full text of the article at 10.1002/cplu.201700539.",

author = "Shirin Kahremany and Ilana Babaev and Pinhas Hasin and Tamir, \{Tigist Y.\} and Tali Ben-Zur and Guy Cohen and Zhengyu Jiang and Sagiv Weintraub and Daniel Offen and Shai Rahimipour and Major, \{M. Ben\} and Hanoch Senderowitz and Arie Gruzman",

note = "Publisher Copyright: {\textcopyright} 2018 Wiley-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2018",

month = may,

doi = "10.1002/cplu.201800155",

language = "الإنجليزيّة",

volume = "83",

pages = "318",

journal = "ChemPlusChem",

issn = "2192-6506",

publisher = "Wiley-VCH Verlag",

number = "5",

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Kahremany, S, Babaev, I, Hasin, P, Tamir, TY, Ben-Zur, T, Cohen, G, Jiang, Z, Weintraub, S, Offen, D , Rahimipour, S, Major, MB, Senderowitz, H & Gruzman, A 2018, 'Computer-Aided Design and Synthesis of 1-{4-[(3,4-Dihydroxybenzylidene)amino]phenyl}-5-oxopyrrolidine-3-carboxylic Acid as an Nrf2 Enhancer', ChemPlusChem, vol. 83, no. 5, pp. 318. https://doi.org/10.1002/cplu.201800155

TY - JOUR

T1 - Computer-Aided Design and Synthesis of 1-{4-[(3,4-Dihydroxybenzylidene)amino]phenyl}-5-oxopyrrolidine-3-carboxylic Acid as an Nrf2 Enhancer

AU - Kahremany, Shirin

AU - Babaev, Ilana

AU - Hasin, Pinhas

AU - Tamir, Tigist Y.

AU - Ben-Zur, Tali

AU - Cohen, Guy

AU - Jiang, Zhengyu

AU - Weintraub, Sagiv

AU - Offen, Daniel

AU - Rahimipour, Shai

AU - Major, M. Ben

AU - Senderowitz, Hanoch

AU - Gruzman, Arie

PY - 2018/5

Y1 - 2018/5

N2 - Invited for this month's cover is Prof. Arie Gruzman (Bar-Ilan University) and collaborators who have developed an Nrf2 enhancer. This compound activated the Nrf2 transduction pathway and because of this the translation of dozens of antioxidant cytoprotective proteins in a dose- and time-dependent manner and protected PC-12 cells against oxidative stress. Considering the imbalance between production and elimination of oxidative species involved in the pathophysiology of many human diseases, this compound is a promising starting point for the development of novel therapeutics for the treatment of oxidative-stress-related diseases. Read the full text of the article at 10.1002/cplu.201700539.

AB - Invited for this month's cover is Prof. Arie Gruzman (Bar-Ilan University) and collaborators who have developed an Nrf2 enhancer. This compound activated the Nrf2 transduction pathway and because of this the translation of dozens of antioxidant cytoprotective proteins in a dose- and time-dependent manner and protected PC-12 cells against oxidative stress. Considering the imbalance between production and elimination of oxidative species involved in the pathophysiology of many human diseases, this compound is a promising starting point for the development of novel therapeutics for the treatment of oxidative-stress-related diseases. Read the full text of the article at 10.1002/cplu.201700539.

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U2 - 10.1002/cplu.201800155

DO - 10.1002/cplu.201800155

M3 - تعليقَ / نقاش

C2 - 31957368

SN - 2192-6506

VL - 83

SP - 318

JO - ChemPlusChem

JF - ChemPlusChem

IS - 5

ER -

Computer-Aided Design and Synthesis of 1-{4-[(3,4-Dihydroxybenzylidene)amino]phenyl}-5-oxopyrrolidine-3-carboxylic Acid as an Nrf2 Enhancer

Abstract

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