Computational design of antibodies

Sharon Fischman, Yanay Ofran

Research output: Contribution to journalReview articlepeer-review


Antibody design aims to create new antibodies with biological activity that can be used in therapy and research. Traditional methods for antibody discovery, such as animal immunization and large-scale library screening, generate antibodies that bind to the target of interest, but do not necessarily have the desired functional effect. Computational methods can be utilized as a means to guide the search for biologically relevant antibodies, focusing on specificity and affinity determinants to target a particular region of the antigen. Such an approach would allow for the design of epitope-specific antibodies that will have the desired effect on the function of the targeted protein.

Original languageEnglish
Pages (from-to)156-162
Number of pages7
JournalCurrent Opinion in Structural Biology
StatePublished - Aug 2018

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Structural Biology


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