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Computational analysis of nucleosome positioning

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Genome-wide patterns of nucleosome occupancy and positioning have greatly impacted on studies of chromatin structure, yet these studies require extensive computational analysis which is crucial for the quality of the resulting datasets and inferred conclusions. This chapter describes the computational steps required in order to estimate genome-wide patterns of nucleosome occupancy and positioning from raw data obtained from high-throughput sequencing of mononucleosome DNA fragments. Potential pitfalls that may be encountered in such analysis and computational quality controls are further discussed in Subheading 3.

Original languageEnglish
Title of host publicationChromatin Remodeling
Subtitle of host publicationMetthods And Protocols
EditorsRandall H. Morse
PublisherHumana Press
Pages443-449
Number of pages7
ISBN (Electronic)978-1-61779-477-3
ISBN (Print)9781617794766
DOIs
StatePublished Online - 21 Nov 2011

Publication series

NameMethods in Molecular Biology
Volume833

All Science Journal Classification (ASJC) codes

  • Genetics
  • Molecular Biology

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