COMPOSITION AND METHODS FOR IDENTIFYING ANTISENSE GUIDE RNA FOR RNA EDITING

Compositions and methods for identifying antisense guide RNA for RNA editing are provided. Accordingly, there is provided a polynucleotide comprising: (i) a nucleic acid sequence encoding a reporter polypeptide comprising a heterologous nucleic acid sequence introducing an in-frame premature stop codon comprising an adenosine preventing translation of a functional reporter polypeptide; and (ii) an additional nucleic acid sequence heterologous to said reporter polypeptide having at least 60% complementarity to said nucleic acid sequence comprising said in-frame premature stop codon.