Competitive fungal commensalism mitigates candidiasis pathology

Jarmila Sekeresova Kralova, Catalina Donic, Bareket Dassa, Ilana Livyatan, Paul Mathias Jansen, Shifra Ben-Dor, Lena Fidel, Sébastien Trzebanski, Lian Narunsky-Haziza, Omer Asraf, Ori Brenner, Hagit Dafni, Ghil Jona, Sigalit Boura-Halfon, Noa Stettner, Eran Segal, Sascha Brunke, Yitzhak Pilpel, Ravid Straussman, David ZeeviPetra Bacher, Bernhard Hube, Neta Shlezinger, Steffen Jung

Research output: Contribution to journalArticlepeer-review


The mycobiota are a critical part of the gut microbiome, but host-fungal interactions and specific functional contributions of commensal fungi to host fitness remain incompletely understood. Here, we report the identification of a new fungal commensal, Kazachstania heterogenica var. weizmannii, isolated from murine intestines. K. weizmannii exposure prevented Candida albicans colonization and significantly reduced the commensal C. albicans burden in colonized animals. Following immunosuppression of C. albicans colonized mice, competitive fungal commensalism thereby mitigated fatal candidiasis. Metagenome analysis revealed K. heterogenica or K. weizmannii presence among human commensals. Our results reveal competitive fungal commensalism within the intestinal microbiota, independent of bacteria and immune responses, that could bear potential therapeutic value for the management of C. albicans-mediated diseases.

Original languageAmerican English
Article numbere20231686
JournalJournal of Experimental Medicine
Issue number5
Early online date18 Mar 2024
StatePublished - 6 May 2024

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology


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