TY - JOUR
T1 - Compartmentalized Signaling in Neurons
T2 - From Cell Biology to Neuroscience
AU - Terenzio, Marco
AU - Schiavo, Giampietro
AU - Fainzilber, Mike
N1 - We apologize to the many authors whose contributions could not be cited due to space constraints. Our work in this area was supported by a Koshland Senior Postdoctoral Award (M.T.), the European Research Council (Advanced Grant Neurogrowth, 339495, M.F.), the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (M.F.), the Israel Science Foundation (1284/13, M.F.), the Minerva Foundation (M.F.), the Wellcome Trust (Senior Investigator Award 107116/Z/15/Z, G.S.), the European Union Horizon 2020 Research and Innovation program (739572, G.S.), and a UK Dementia Research Institute award (G.S.).
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Neurons are the largest known cells, with complex and highly polarized morphologies. As such, neuronal signaling is highly compartmentalized, requiring sophisticated transfer mechanisms to convey and integrate information within and between sub-neuronal compartments. Here, we survey different modes of compartmentalized signaling in neurons, highlighting examples wherein the fundamental cell biological processes of protein synthesis and degradation, membrane trafficking, and organelle transport are employed to enable the encoding and integration of information, locally and globally within a neuron. Comparisons to other cell types indicate that neurons accentuate widely shared mechanisms, providing invaluable models for the compartmentalization and transfer mechanisms required and used by most eukaryotic cells. Terenzio et al. survey the influence of neuronal size and polarization on compartmentalized signaling, highlighting roles for protein synthesis and degradation, membrane trafficking, and organelle transport. Neuronal mechanisms provide invaluable models for studying the cell biology of signaling in diverse cell types.
AB - Neurons are the largest known cells, with complex and highly polarized morphologies. As such, neuronal signaling is highly compartmentalized, requiring sophisticated transfer mechanisms to convey and integrate information within and between sub-neuronal compartments. Here, we survey different modes of compartmentalized signaling in neurons, highlighting examples wherein the fundamental cell biological processes of protein synthesis and degradation, membrane trafficking, and organelle transport are employed to enable the encoding and integration of information, locally and globally within a neuron. Comparisons to other cell types indicate that neurons accentuate widely shared mechanisms, providing invaluable models for the compartmentalization and transfer mechanisms required and used by most eukaryotic cells. Terenzio et al. survey the influence of neuronal size and polarization on compartmentalized signaling, highlighting roles for protein synthesis and degradation, membrane trafficking, and organelle transport. Neuronal mechanisms provide invaluable models for studying the cell biology of signaling in diverse cell types.
UR - http://www.scopus.com/inward/record.url?scp=85033593152&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.neuron.2017.10.015
DO - https://doi.org/10.1016/j.neuron.2017.10.015
M3 - مقالة مرجعية
SN - 0896-6273
VL - 96
SP - 667
EP - 679
JO - Neuron
JF - Neuron
IS - 3
ER -