Comparison of equations estimating resting metabolic rate in older adults with type 2 diabetes

Assaf Buch, Jonathan Diener, Naftali Stern, Amir Rubin, Ofer Kis, Yael Sofer, Mariana Yaron, Yona Greenman, Roy Eldor, Sigal Eilat-Adar

Research output: Contribution to journalArticlepeer-review


Measuring resting metabolic rate (RMR) is time-consuming and expensive, and thus various equations for estimating RMR have been developed. This study’s objective was to compare five equations in elderly people with type 2 diabetes (T2DM). RMR was measured in 90 older adults (≥65 years) with T2DM (mean body mass index (BMI) of 31.5 kg/m2), using indirect calorimetry. Results were compared to four frequently used equations (those of Cunningham, Harris and Benedict, and Gougeon developed for young adults with T2DM, and that of Lührmann, which was developed for the elderly), in addition to a new equation developed recently at the Academic College at Wingate (Nachmani) for overweight individuals. Estimation accuracy was defined as the percentage of subjects with calculated RMR within ±10% of measured RMR. Measured RMR was significantly underestimated by all equations. The equations of Nachmani and Lührmann had the best estimation accuracy: 71.4% in males and 50.9% in females. Skeletal muscle mass, fat mass, hemoglobin A1c (HbA1c), and the use of insulin explained 70.6% of the variability in measured RMR. RMR in elderly participants with T2DM was higher than that calculated using existing equations. The most accurate equations for this specific population were those developed for obesity or the elderly. Unbalanced T2DM may increase caloric demands in the elderly. It is recommended to adjust the RMR equations used for the target population.

Original languageEnglish
Article number1644
JournalJournal of Clinical Medicine
Issue number8
StatePublished - 2 Apr 2021


  • Elderly
  • Energy expenditure
  • Obesity
  • Predictive equations
  • Resting metabolic rate
  • Type 2 diabetes

All Science Journal Classification (ASJC) codes

  • Medicine(all)


Dive into the research topics of 'Comparison of equations estimating resting metabolic rate in older adults with type 2 diabetes'. Together they form a unique fingerprint.

Cite this