Comparative Review of the Conserved UL24 Protein Family in Herpesviruses

Odelia Orbaum-Harel; Ronit Sarid

doi:10.3390/ijms252011268

Comparative Review of the Conserved UL24 Protein Family in Herpesviruses

Odelia Orbaum-Harel, Ronit Sarid

The Mina and Everard Goodman Faculty of Life Sciences - at Bar-Ilan University

Bar-Ilan University

Research output: Contribution to journal › Review article › peer-review

Abstract

The UL24 protein family, conserved across all subfamilies of Orthoherpesviridae, plays diverse and significant roles in viral replication, host–virus interactions and pathogenesis. Understanding the molecular mechanisms and interactions of UL24 proteins is key to unraveling the complex interplay between herpesviruses and their hosts. This review provides a comparative and comprehensive overview of current knowledge on UL24 family members, including their conservation, expression patterns, cellular localization, and functional roles upon their expression and during viral infection, highlighting their significance in herpesvirus biology and their potential functions.

Original language	English
Article number	11268
Journal	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume	25
Issue number	20
DOIs	https://doi.org/10.3390/ijms252011268
State	Published - 19 Oct 2024

Keywords

ORF35
UL24
UL76
herpesvirus
open reading frame 20 (ORF20)

All Science Journal Classification (ASJC) codes

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.3390/ijms252011268

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title = "Comparative Review of the Conserved UL24 Protein Family in Herpesviruses",

abstract = "The UL24 protein family, conserved across all subfamilies of Orthoherpesviridae, plays diverse and significant roles in viral replication, host–virus interactions and pathogenesis. Understanding the molecular mechanisms and interactions of UL24 proteins is key to unraveling the complex interplay between herpesviruses and their hosts. This review provides a comparative and comprehensive overview of current knowledge on UL24 family members, including their conservation, expression patterns, cellular localization, and functional roles upon their expression and during viral infection, highlighting their significance in herpesvirus biology and their potential functions.",

keywords = "ORF35, UL24, UL76, herpesvirus, open reading frame 20 (ORF20)",

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AU - Sarid, Ronit

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N2 - The UL24 protein family, conserved across all subfamilies of Orthoherpesviridae, plays diverse and significant roles in viral replication, host–virus interactions and pathogenesis. Understanding the molecular mechanisms and interactions of UL24 proteins is key to unraveling the complex interplay between herpesviruses and their hosts. This review provides a comparative and comprehensive overview of current knowledge on UL24 family members, including their conservation, expression patterns, cellular localization, and functional roles upon their expression and during viral infection, highlighting their significance in herpesvirus biology and their potential functions.

AB - The UL24 protein family, conserved across all subfamilies of Orthoherpesviridae, plays diverse and significant roles in viral replication, host–virus interactions and pathogenesis. Understanding the molecular mechanisms and interactions of UL24 proteins is key to unraveling the complex interplay between herpesviruses and their hosts. This review provides a comparative and comprehensive overview of current knowledge on UL24 family members, including their conservation, expression patterns, cellular localization, and functional roles upon their expression and during viral infection, highlighting their significance in herpesvirus biology and their potential functions.

KW - ORF35

KW - UL24

KW - UL76

KW - herpesvirus

KW - open reading frame 20 (ORF20)

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U2 - 10.3390/ijms252011268

DO - 10.3390/ijms252011268

M3 - مقالة مرجعية

C2 - 39457049

SN - 1661-6596

VL - 25

JO - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IS - 20

M1 - 11268

ER -

Comparative Review of the Conserved UL24 Protein Family in Herpesviruses

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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