TY - JOUR
T1 - Comparative "omics" of the fusarium fujikuroi species complex highlights differences in genetic potential and metabolite synthesis
AU - Niehaus, Eva Maria
AU - Münsterkötter, Martin
AU - Proctor, Robert H.
AU - Brown, Daren W.
AU - Sharon, Amir
AU - Idan, Yifat
AU - Oren-Young, Liat
AU - Sieber, Christian M.
AU - Novák, Ondřej
AU - Pěnčík, Aleš
AU - Tarkowská, Danuše
AU - Hromadová, Kristýna
AU - Freeman, Stanley
AU - Maymon, Marcel
AU - Elazar, Meirav
AU - Youssef, Sahar A.
AU - El-Shabrawy, El Said M.
AU - Shalaby, Abdel Baset A.
AU - Houterman, Petra
AU - Brock, Nelson L.
AU - Burkhardt, Immo
AU - Tsavkelova, Elena A.
AU - Dickschat, Jeroen S.
AU - Galuszka, Petr
AU - Güldener, Ulrich
AU - Tudzynski, Bettina
N1 - Publisher Copyright: © The Author(s) 2016.
PY - 2016/11
Y1 - 2016/11
N2 - Species of the Fusarium fujikuroi species complex (FFC) cause a wide spectrum of often devastating diseases on diverse agricultural crops, including coffee, fig, mango, maize, rice, and sugarcane. Although species within the FFC are difficult to distinguish by morphology, and their genes often share 90% sequence similarity, they can differ in host plant specificity and life style. FFC species can also produce structurally diverse secondary metabolites (SMs), including the mycotoxins fumonisins, fusarins, fusaric acid, and beauvericin, and the phytohormones gibberellins, auxins, and cytokinins. The spectrum of SMs produced can differ among closely related species, suggesting that SMs might be determinants of host specificity. To date, genomes of only a limited number of FFC species have been sequenced. Here, we provide draft genome sequences of three more members of the FFC: a single isolate of F. mangiferae, the cause of mango malformation, and two isolates of F. proliferatum, one a pathogen of maize and the other an orchidendophyte. Wecomparedthesegenomes to publicly availablegenomesequences of threeother FFCspecies. Thecomparisons revealed species-specific and isolate-specific differences in the composition and expression (in vitro and in planta) of genes involved in SMproduction including those for phytohormomebiosynthesis. Such differences have the potential to impact host specificity and, as in the case of F. proliferatum, the pathogenic versus endophytic life style.
AB - Species of the Fusarium fujikuroi species complex (FFC) cause a wide spectrum of often devastating diseases on diverse agricultural crops, including coffee, fig, mango, maize, rice, and sugarcane. Although species within the FFC are difficult to distinguish by morphology, and their genes often share 90% sequence similarity, they can differ in host plant specificity and life style. FFC species can also produce structurally diverse secondary metabolites (SMs), including the mycotoxins fumonisins, fusarins, fusaric acid, and beauvericin, and the phytohormones gibberellins, auxins, and cytokinins. The spectrum of SMs produced can differ among closely related species, suggesting that SMs might be determinants of host specificity. To date, genomes of only a limited number of FFC species have been sequenced. Here, we provide draft genome sequences of three more members of the FFC: a single isolate of F. mangiferae, the cause of mango malformation, and two isolates of F. proliferatum, one a pathogen of maize and the other an orchidendophyte. Wecomparedthesegenomes to publicly availablegenomesequences of threeother FFCspecies. Thecomparisons revealed species-specific and isolate-specific differences in the composition and expression (in vitro and in planta) of genes involved in SMproduction including those for phytohormomebiosynthesis. Such differences have the potential to impact host specificity and, as in the case of F. proliferatum, the pathogenic versus endophytic life style.
KW - Evolution
KW - Fusarium fujikuroi species complex
KW - Genome sequencing
KW - In planta expression
KW - Metabolomics
KW - Secondary metabolism
UR - http://www.scopus.com/inward/record.url?scp=85021198756&partnerID=8YFLogxK
U2 - https://doi.org/10.1093/gbe/evw259
DO - https://doi.org/10.1093/gbe/evw259
M3 - مقالة
C2 - 28040774
SN - 1759-6653
VL - 8
SP - 3574
EP - 3599
JO - Genome Biology and Evolution
JF - Genome Biology and Evolution
IS - 11
ER -