@article{958903bc48d64e298203dd32291a1f1a,
title = "Comparative Metabolomics and Molecular Phylogenetics of Melon (Cucumis melo, Cucurbitaceae) Biodiversity",
abstract = "The broad variability of Cucumis melo (melon, Cucurbitaceae) presents a challenge to conventional classification and organization within the species. To shed further light on the infraspecific relationships within C. melo, we compared genotypic and metabolomic similarities among 44 accessions representative of most of the cultivar-groups. Genotyping-by-sequencing (GBS) provided over 20,000 single-nucleotide polymorphisms (SNPs). Metabolomics data of the mature fruit flesh and rind provided over 80,000 metabolomic and elemental features via an orchestra of six complementary metabolomic platforms. These technologies probed polar, semi-polar, and non-polar metabolite fractions as well as a set of mineral elements and included both flavor- and taste-relevant volatile and non-volatile metabolites. Together these results enabled an estimate of {"}metabolomic/elemental distance{"} and its correlation with the genetic GBS distance of melon accessions. This study indicates that extensive and non-targeted metabolomics/elemental characterization produced classifications that strongly, but not completely, reflect the current and extensive genetic classification. Certain melon Groups, such as Inodorous, clustered in parallel with the genetic classifications while other genome to metabolome/element associations proved less clear. We suggest that the combined genomic, metabolic, and element data reflect the extensive sexual compatibility among melon accessions and the breeding history that has, for example, targeted metabolic quality traits, such as taste and flavor.",
author = "Annick Moing and Allwood, {J. William} and Asaph Aharoni and John Baker and Beale, {Michael H.} and Shifra Ben-Dor and Benoit Biais and Federico Brigante and Yosef Burger and Catherine Deborde and Alexander Erban and Adi Faigenboim and Amit Gur and Royston Goodacre and Hansen, {Thomas H.} and Daniel Jacob and Nurit Katzir and Joachim Kopka and Efraim Lewinsohn and Mickael Maucourt and Sagit Meir and Sonia Miller and Roland Mumm and Elad Oren and Paris, {Harry S.} and Ilana Rogachev and Dominique Rolin and Uzi Saar and Schjoerring, {Jan K.} and Yaakov Tadmor and Galil Tzuri and {de Vos}, {Ric C. H.} and Ward, {Jane L.} and Elena Yeselson and Hall, {Robert D.} and Schaffer, {Arthur A.}",
note = "This article belongs to the Special Issue Fruit Metabolism and Metabolomics. Author Contributions Conceptualization, A.A.S. and R.D.H.; sample preparation and biochemical analyses, A.A., J.W.A., B.B., J.B., M.H.B., C.D., A.E., R.G., T.H.H., D.R., M.M., S.M. (Sagit Meir), S.M. (Sonia Miller), R.M., I.R., J.K.S., R.C.H.d.V., J.L.W., E.Y.; genetic analyses, A.G., N.K., E.O., H.S.P., E.L., U.S., Y.T., Y.B., A.F., S.B.-D., G.T. data curation and mining, F.B., A.E., D.J., J.K., A.M.; writing and original draft preparation, A.E., R.D.H., J.K., A.M., H.S.P., A.A.S.; manuscript reviewing and editing, all authors; funding acquisition, R.D.H. All authors have read and agreed to the submitted version of the manuscript. Funding The data presented in this paper were generated within the META-PHOR project financed by the European Union Framework 6 programme [2006-FOODCT-036220]. Acknowledgments A.E. and J.K. acknowledge technical and laboratory support of the GC-MS analyses by Ines Fehrle.",
year = "2020",
month = mar,
day = "24",
doi = "10.3390/metabo10030121",
language = "الإنجليزيّة",
volume = "10",
journal = "Metabolites",
issn = "2218-1989",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "3",
}