TY - JOUR
T1 - Comparative analysis of classic network vs. nanogel junction network in konjac glucomannan/kappa carrageenan hybrid hydrogels
AU - Peleg-Evron, Or
AU - Wirzeberger, Dana
AU - Davidovich-Pinhas, Maya
AU - Cometa, Stefania
AU - De Giglio, Elvira
AU - Bianco-Peled, Havazelet
N1 - Publisher Copyright: © 2024 Elsevier B.V.
PY - 2024/11
Y1 - 2024/11
N2 - The three-dimensional network architecture of hydrogels significantly influences their mechanical and physical properties; therefore, understanding them is essential for designing optimized hydrogel-based biomaterials. This study presents a comparative analysis of two hybrid hydrogels composed of konjac glucomannan (KGM) and kappa carrageenan (KCAR) with the same stiffness (5.2–5.7 kPa and 1.6–1.7 kPa) thus similar cross-linking density but different network architectures: a classic network formed by extended polysaccharide interactions and a nanogel junction network where nanoscale cross-linked KCAR (KCAR-NGs) links KGM chains. The mechanical behavior, dissolution, and diffusion characteristics were examined, revealing that the classic network demonstrates superior tensile resistance, elongation, and solvent-induced swelling resistance, leading to slower dissolution rates and higher viscosity. Conversely, the nanogel junction network offers higher permeability for small molecules and faster dissolution, suggesting a more open network structure. These findings highlight the nanogel-based hydrogels' advantages for biomedical applications requiring stability, permeability, and rapid dissolution without high temperatures or chelating agents. This study underscores the potential of nanogel junction networks to balance hydrogel stiffness and permeability, advancing the design of hydrogel-based biomaterials.
AB - The three-dimensional network architecture of hydrogels significantly influences their mechanical and physical properties; therefore, understanding them is essential for designing optimized hydrogel-based biomaterials. This study presents a comparative analysis of two hybrid hydrogels composed of konjac glucomannan (KGM) and kappa carrageenan (KCAR) with the same stiffness (5.2–5.7 kPa and 1.6–1.7 kPa) thus similar cross-linking density but different network architectures: a classic network formed by extended polysaccharide interactions and a nanogel junction network where nanoscale cross-linked KCAR (KCAR-NGs) links KGM chains. The mechanical behavior, dissolution, and diffusion characteristics were examined, revealing that the classic network demonstrates superior tensile resistance, elongation, and solvent-induced swelling resistance, leading to slower dissolution rates and higher viscosity. Conversely, the nanogel junction network offers higher permeability for small molecules and faster dissolution, suggesting a more open network structure. These findings highlight the nanogel-based hydrogels' advantages for biomedical applications requiring stability, permeability, and rapid dissolution without high temperatures or chelating agents. This study underscores the potential of nanogel junction networks to balance hydrogel stiffness and permeability, advancing the design of hydrogel-based biomaterials.
KW - Dissolution
KW - Hydrogels
KW - Kappa carrageenan
KW - Konjac glucomannan
KW - Nanogels
UR - http://www.scopus.com/inward/record.url?scp=85204076259&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.ijbiomac.2024.135244
DO - https://doi.org/10.1016/j.ijbiomac.2024.135244
M3 - مقالة
SN - 0141-8130
VL - 279
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
M1 - 135244
ER -