Abstract
Open sesame! Compounds that correct the folding, trafficking and gating defects in cystic fibrosis transmembrane conductance regulator (CFTR), the main protein implicated in cystic fibrosis (CF), are of great interest as potential therapeutic agents for this lethal disease. The development of CFTR modulators, highlighting the main challenges in the field and advocating the application of rational rather than brute-force methods, is the focus of this Minireview.
| Original language | English |
|---|---|
| Pages (from-to) | 243-251 |
| Number of pages | 9 |
| Journal | ChemMedChem |
| Volume | 6 |
| Issue number | 2 |
| DOIs | |
| State | Published - 7 Feb 2011 |
Keywords
- Computer-aided drug design
- Cystic fibrosis
- Cystic fibrosis transmembrane conductance regulator (CFTR)
- Modulators
- Rational drug design
All Science Journal Classification (ASJC) codes
- Drug Discovery
- General Pharmacology, Toxicology and Pharmaceutics
- Molecular Medicine
- Biochemistry
- Pharmacology
- Organic Chemistry