Cold spots are universal in protein–protein interactions

Keyphrases

• Protein-protein Interaction 100%
• Cold Spot 100%
• Binding Interface 27%
• Amino Acids 18%
• Binding Affinity 18%
• Homodimer 18%
• Charge Interaction 18%
• Spot Position 18%
• Arginine 9%
• High Affinity 9%
• Glutamate 9%
• Physicochemical Properties 9%
• Binding Specificity 9%
• Glycine 9%
• Binding Energy 9%
• Protein Data Bank 9%
• Engineering Studies 9%
• Low Affinity 9%
• Heterocomplex 9%
• First Use 9%
• Homodimeric 9%
• Protein Engineering 9%
• Protein Evolution 9%
• Symmetry Constraints 9%
• Dimeric Complex 9%
• Cognate Interaction 9%
• Noncognate 9%
• Spot Analysis 9%
• Affinity Enhancement 9%

Biochemistry, Genetics and Molecular Biology

• Amino Acid 100%
• Binding Affinity 100%
• Arginine 50%
• Protein Data Bank 50%
• Protein Engineering 50%