@article{de6341b03944403a9648c184b1b3a8c9,
title = "Cochlear neural degeneration disrupts hearing in background noise by increasing auditory cortex internal noise",
abstract = "Resnik and Polley show that selective difficulty hearing in noise can be induced in mice through degeneration of primary afferent neurons in the auditory nerve. Primary afferent lesions dysregulate activity in the auditory cortex, producing surges of noisy, synchronized activity that specifically preceded failures to detect target sounds in noise.",
keywords = "auditory cortex, hearing in noise, hidden hearing loss, homeostatic plasticity, nerve damage, neuropathy, parvalbumin, spiral ganglion, synaptopathy, two-photon calcium imaging",
author = "Jennifer Resnik and Polley, {Daniel B.}",
note = "Funding Information: We thank Aravind Parthasarathy for providing the cochlear histology and imaging shown in Figure 1 . We thank Ken Hancock and Ross Williamson for support with data collection software. We thank the GENIE Program, the Janelia Farm Research Campus, and Addgene for providing the GCaMP6s reagent for this project. This work was supported by NIH grant DC009836 (D.B.P.), The Nancy Lurie Marks Family Foundation (D.B.P.), the Hearing Health Foundation and Hyperacusis Research (J.R.), and a Cohen Family Tinnitus Fellowship (J.R.). Funding Information: We thank Aravind Parthasarathy for providing the cochlear histology and imaging shown in Figure 1. We thank Ken Hancock and Ross Williamson for support with data collection software. We thank the GENIE Program, the Janelia Farm Research Campus, and Addgene for providing the GCaMP6s reagent for this project. This work was supported by NIH grant DC009836 (D.B.P.), The Nancy Lurie Marks Family Foundation (D.B.P.), the Hearing Health Foundation and Hyperacusis Research (J.R.), and a Cohen Family Tinnitus Fellowship (J.R.). D.B.P. and J.R. designed the experiments. J.R. performed all experiments and analysis with supervisory input from D.B.P. D.B.P. wrote the manuscript with input from J.R. D.B.P. is a member of the Neuron scientific advisory board. Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",
year = "2021",
month = mar,
day = "17",
doi = "10.1016/j.neuron.2021.01.015",
language = "American English",
volume = "109",
pages = "984--996.e4",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "6",
}