Abstract
Cl- is the major extracellular (Cl- out) and intracellular (Cl- in) anion whose concentration is actively regulated by multiple transporters. These transporters generate Cl- gradients across the plasma membrane and between the cytoplasm and intracellular organelles. [Cl-]in changes rapidly in response to cell stimulation and influences many physiological functions, as well as cellular and systemic homeostasis. However, less appreciated is the signaling function of Cl-. Cl- interacts with multiple proteins to directly modify their activity. This review highlights the signaling function of Cl- and argues that Cl- is a bona fide signaling ion, a function deserving extensive exploration.
Original language | American English |
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Pages (from-to) | C125-C136 |
Journal | American Journal of Physiology - Cell Physiology |
Volume | 318 |
Issue number | 1 |
DOIs | |
State | Published - 1 Jan 2020 |
Keywords
- Chloride
- Signaling
All Science Journal Classification (ASJC) codes
- Physiology
- Cell Biology