Closed-loop neuromodulation for studying spontaneous activity and causality

Michal Ramot, Alex Martin

Research output: Contribution to journalReview articlepeer-review

Abstract

Having established that spontaneous brain activity follows meaningful coactivation patterns and correlates with behavior, researchers have turned their attention to understanding its function and behavioral significance. We suggest closed-loop neuromodulation as a neural perturbation tool uniquely well suited for this task. Closed-loop neuromodulation has primarily been viewed as an interventionist tool to teach subjects to directly control their own brain activity. We examine an alternative operant conditioning model of closed-loop neuromodulation which, through implicit feedback, can manipulate spontaneous activity at the network level, without violating the spontaneous or endogenous nature of the signal, thereby providing a direct test of network causality.
Original languageEnglish
Pages (from-to)290-299
Number of pages10
JournalTrends in Cognitive Sciences
Volume26
Issue number4
Early online date21 Feb 2022
DOIs
StatePublished - Apr 2022

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience

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