Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell Genome Sequencing

doi:10.1016/j.cell.2019.10.026

Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell Genome Sequencing

Bar-Ilan University - The Alexander Kofkin Faculty of Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

A high-throughput method for amplication-free single-cell whole-genome sequencing can be scaled up to analyze tens of thousands of cells from different tissues and clinical sample types and identifies replication states, aneuploidies, and subclonal mutations.

Original language	English
Pages (from-to)	1207-1221.e22
Journal	Cell
Volume	179
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2019.10.026
State	Published - 14 Nov 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

DNA sequencing
aneuploidy
cancer genomics
cell cycle
copy number
genomic instability
single cell
tumor evolution
tumor heterogeneity

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology

Access to Document

10.1016/j.cell.2019.10.026

Cite this

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title = "Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell Genome Sequencing",

abstract = "A high-throughput method for amplication-free single-cell whole-genome sequencing can be scaled up to analyze tens of thousands of cells from different tissues and clinical sample types and identifies replication states, aneuploidies, and subclonal mutations.",

keywords = "DNA sequencing, aneuploidy, cancer genomics, cell cycle, copy number, genomic instability, single cell, tumor evolution, tumor heterogeneity",

author = "Emma Laks and Andrew McPherson and Hans Zahn and Daniel Lai and Adi Steif and Jazmine Brimhall and Justina Biele and Beixi Wang and Tehmina Masud and Jerome Ting and Diljot Grewal and Cydney Nielsen and Samantha Leung and Viktoria Bojilova and Maia Smith and Oleg Golovko and Steven Poon and Peter Eirew and Farhia Kabeer and \{Ruiz de Algara\}, Teresa and Lee, \{So Ra\} and Taghiyar, \{M. Jafar\} and Curtis Huebner and Jessica Ngo and Tim Chan and Spencer Vatrt-Watts and Pascale Walters and Nafis Abrar and Sophia Chan and Matt Wiens and Lauren Martin and Scott, \{R. Wilder\} and Underhill, \{T. Michael\} and Elizabeth Chavez and Christian Steidl and \{Da Costa\}, Daniel and Yussanne Ma and Coope, \{Robin J.N.\} and Richard Corbett and Stephen Pleasance and Richard Moore and Mungall, \{Andrew J.\} and Colin Mar and Fergus Cafferty and Karen Gelmon and Stephen Chia and Hannon, \{Gregory J.\} and Giorgia Battistoni and Dario Bressan and Shahar Alon",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = nov,

day = "14",

doi = "10.1016/j.cell.2019.10.026",

language = "الإنجليزيّة",

volume = "179",

pages = "1207--1221.e22",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier B.V.",

number = "5",

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T1 - Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell Genome Sequencing

AU - Laks, Emma

AU - McPherson, Andrew

AU - Zahn, Hans

AU - Lai, Daniel

AU - Steif, Adi

AU - Brimhall, Jazmine

AU - Biele, Justina

AU - Wang, Beixi

AU - Masud, Tehmina

AU - Ting, Jerome

AU - Grewal, Diljot

AU - Nielsen, Cydney

AU - Leung, Samantha

AU - Bojilova, Viktoria

AU - Smith, Maia

AU - Golovko, Oleg

AU - Poon, Steven

AU - Eirew, Peter

AU - Kabeer, Farhia

AU - Ruiz de Algara, Teresa

AU - Lee, So Ra

AU - Taghiyar, M. Jafar

AU - Huebner, Curtis

AU - Ngo, Jessica

AU - Chan, Tim

AU - Vatrt-Watts, Spencer

AU - Walters, Pascale

AU - Abrar, Nafis

AU - Chan, Sophia

AU - Wiens, Matt

AU - Martin, Lauren

AU - Scott, R. Wilder

AU - Underhill, T. Michael

AU - Chavez, Elizabeth

AU - Steidl, Christian

AU - Da Costa, Daniel

AU - Ma, Yussanne

AU - Coope, Robin J.N.

AU - Corbett, Richard

AU - Pleasance, Stephen

AU - Moore, Richard

AU - Mungall, Andrew J.

AU - Mar, Colin

AU - Cafferty, Fergus

AU - Gelmon, Karen

AU - Chia, Stephen

AU - Hannon, Gregory J.

AU - Battistoni, Giorgia

AU - Bressan, Dario

AU - Alon, Shahar

PY - 2019/11/14

Y1 - 2019/11/14

N2 - A high-throughput method for amplication-free single-cell whole-genome sequencing can be scaled up to analyze tens of thousands of cells from different tissues and clinical sample types and identifies replication states, aneuploidies, and subclonal mutations.

AB - A high-throughput method for amplication-free single-cell whole-genome sequencing can be scaled up to analyze tens of thousands of cells from different tissues and clinical sample types and identifies replication states, aneuploidies, and subclonal mutations.

KW - DNA sequencing

KW - aneuploidy

KW - cancer genomics

KW - cell cycle

KW - copy number

KW - genomic instability

KW - single cell

KW - tumor evolution

KW - tumor heterogeneity

UR - http://www.scopus.com/inward/record.url?scp=85074692972&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2019.10.026

DO - 10.1016/j.cell.2019.10.026

M3 - مقالة

C2 - 31730858

SN - 0092-8674

VL - 179

SP - 1207-1221.e22

JO - Cell

JF - Cell

IS - 5

ER -

Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell Genome Sequencing

Abstract

UN SDGs

Keywords

All Science Journal Classification (ASJC) codes

Access to Document

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