Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell Genome Sequencing

Research output: Contribution to journalArticlepeer-review

Abstract

A high-throughput method for amplication-free single-cell whole-genome sequencing can be scaled up to analyze tens of thousands of cells from different tissues and clinical sample types and identifies replication states, aneuploidies, and subclonal mutations.

Original languageEnglish
Pages (from-to)1207-1221.e22
JournalCell
Volume179
Issue number5
DOIs
StatePublished - 14 Nov 2019

Keywords

  • DNA sequencing
  • aneuploidy
  • cancer genomics
  • cell cycle
  • copy number
  • genomic instability
  • single cell
  • tumor evolution
  • tumor heterogeneity

All Science Journal Classification (ASJC) codes

  • General Biochemistry,Genetics and Molecular Biology

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