Clinical features and comparison of kingella and non-kingella endocarditis in children, Israel

Hila Weisblum-Neuman, Einat Birk, Liat Ashkenazi-Hoffnung, Itzhak Levy, Gabriel Amir, Georgy Frenkel, Elchanan Bruckheimer, Havatzelet Yarden-Bilavsky, Dafna Marom, Eran Shostak, Tamir Dagan, Gabriel Chodick, Oded Scheuerman

Research output: Contribution to journalArticlepeer-review


Kingella spp. have emerged as an important cause of invasive pediatric diseases. Data on Kingella infective endocarditis (KIE) in children are scarce. We compared the clinical features of pediatric KIE cases with those of Streptococcus species IE (StIE) and Staphylococcus aureus IE (SaIE). A total of 60 patients were included in the study. Throughout the study period, a rise in incidence of KIE was noted. KIE patients were significantly younger than those with StIE and SaIE, were predominately boys, and had higher temperature at admission, history of oral aphthae before IE diagnosis, and higher lymphocyte count (p<0.05). Pediatric KIE exhibits unique features compared with StIE and SaIE. Therefore, in young healthy children <36 months of age, especially boys, with or without a congenital heart defect, with a recent history of oral aphthae, and experiencing signs and symptoms compatible with endocarditis, Kingella should be suspected as the causative pathogen.

Original languageEnglish
Pages (from-to)703-709
Number of pages7
JournalEmerging Infectious Diseases
Issue number3
StatePublished - Mar 2021

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases
  • Epidemiology


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