Click-to-lead design of a picomolar ABA receptor antagonist with potent activity in vivo

Keyphrases

• Abscisic Acid 100%
• Activity in Vivo 100%
• Receptor Antagonist 100%
• Abscisic Acid Receptor 100%
• Lead Design 100%
• Arabidopsis 66%
• High Affinity 66%
• Seed Germination 66%
• Abscisic Acid Signaling 66%
• Opabactin 66%
• Binding Affinity 33%
• Developmental Processes 33%
• Head Group 33%
• Physiological Role 33%
• Barley 33%
• Tomato 33%
• Acid Activation 33%
• Non-canonical 33%
• Plant Hormones 33%
• X-ray Crystal Structure 33%
• Synthetic Agonists 33%
• Fluorescence Polarization 33%
• Plant Abiotic Stress 33%
• Improved Activity 33%
• Biotic Stress Response 33%
• Receptor Antagonism 33%
• Equilibrium Dissociation Constant 33%
• Affinity Probe 33%
• Copper-catalyzed Azide-alkyne Cycloaddition (CuAAC) 33%
• Abiotic Stress Response 33%
• Germination Stimulant 33%

Biochemistry, Genetics and Molecular Biology

• Abscisic Acid 100%
• Receptor Antagonist 100%
• Seed Germination 50%
• Arabidopsis 33%
• Agonist 33%
• Binding Affinity 16%
• Crystal Structure 16%
• X Ray 16%
• Abiotic Stress 16%
• Dissociation Constant 16%
• Click Chemistry 16%