Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases

Elena A. Minina; Jens Staal; Vanina E. Alvarez; John A. Berges; Ilana Berman-Frank; Rudi Beyaert; Kay D. Bidle; Frédéric Bornancin; Magali Casanova; Juan J. Cazzulo; Chang Jae Choi; Nuria S. Coll; Vishva M. Dixit; Marko Dolinar; Nicolas Fasel; Christiane Funk; Patrick Gallois; Kris Gevaert; Emilio Gutierrez-Beltran; Stephan Hailfinger; Marina Klemenčič; Eugene V. Koonin; Daniel Krappmann; Anna Linusson; Maurício F.M. Machado; Frank Madeo; Lynn A. Megeney; Panagiotis N. Moschou; Jeremy C. Mottram; Thomas Nyström; Heinz D. Osiewacz; Christopher M. Overall; Kailash C. Pandey; Jürgen Ruland; Guy S. Salvesen; Yigong Shi; Andrei Smertenko; Simon Stael; Jerry Ståhlberg; María Fernanda Suárez; Margot Thome; Hannele Tuominen; Frank Van Breusegem; Renier A.L. van der Hoorn; Assaf Vardi; Boris Zhivotovsky; Eric Lam; Peter V. Bozhkov

doi:https://doi.org/10.1016/j.molcel.2019.12.020

Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases

Elena A. Minina, Jens Staal, Vanina E. Alvarez, John A. Berges, Ilana Berman-Frank, Rudi Beyaert, Kay D. Bidle, Frédéric Bornancin, Magali Casanova, Juan J. Cazzulo, Chang Jae Choi, Nuria S. Coll, Vishva M. Dixit, Marko Dolinar, Nicolas Fasel, Christiane Funk, Patrick Gallois, Kris Gevaert, Emilio Gutierrez-Beltran, Stephan HailfingerMarina Klemenčič, Eugene V. Koonin, Daniel Krappmann, Anna Linusson, Maurício F.M. Machado, Frank Madeo, Lynn A. Megeney, Panagiotis N. Moschou, Jeremy C. Mottram, Thomas Nyström, Heinz D. Osiewacz, Christopher M. Overall, Kailash C. Pandey, Jürgen Ruland, Guy S. Salvesen, Yigong Shi, Andrei Smertenko, Simon Stael, Jerry Ståhlberg, María Fernanda Suárez, Margot Thome, Hannele Tuominen, Frank Van Breusegem, Renier A.L. van der Hoorn, Assaf Vardi, Boris Zhivotovsky, Eric Lam, Peter V. Bozhkov

University of Haifa, Weizmann Institute of Science

Research output: Contribution to journal › Letter › peer-review

Abstract

Metacaspases and paracaspases are proteases that were first identified as containing a caspase-like structural fold (Uren et al., 2000). Like caspases, meta- and paracaspases are multifunctional proteins regulating diverse biological phenomena, such as aging, immunity, proteostasis and programmed cell death. The broad phylogenetic distribution of meta- and paracaspases across all kingdoms of life and large variation of their biochemical and structural features complicate classification and annotation of the rapidly growing number of identified homologs. Establishment of an adequate classification and unified nomenclature of meta- and paracaspases is especially important to avoid frequent confusion of these proteases with caspases - a tenacious misnomer that unfortunately does not appear to decline with time. This letter represents a consensus opinion of researchers studying different aspects of caspases, meta- and paracaspases in various organisms, ranging from microbes to plants and animals.

Original language	American English
Pages (from-to)	927-929
Number of pages	3
Journal	Molecular Cell
Volume	77
Issue number	5
DOIs	https://doi.org/10.1016/j.molcel.2019.12.020
State	Published - 5 Mar 2020

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

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https://doi.org/10.1016/j.molcel.2019.12.020

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Minina, E. A., Staal, J., Alvarez, V. E., Berges, J. A., Berman-Frank, I., Beyaert, R., Bidle, K. D., Bornancin, F., Casanova, M., Cazzulo, J. J., Choi, C. J., Coll, N. S., Dixit, V. M., Dolinar, M., Fasel, N., Funk, C., Gallois, P., Gevaert, K., Gutierrez-Beltran, E., ... Bozhkov, P. V. (2020). Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases. Molecular Cell, 77(5), 927-929. https://doi.org/10.1016/j.molcel.2019.12.020

@article{0fed45649f1949ab9e1c4dc4b9880320,

title = "Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases",

abstract = "Metacaspases and paracaspases are proteases that were first identified as containing a caspase-like structural fold (Uren et al., 2000). Like caspases, meta- and paracaspases are multifunctional proteins regulating diverse biological phenomena, such as aging, immunity, proteostasis and programmed cell death. The broad phylogenetic distribution of meta- and paracaspases across all kingdoms of life and large variation of their biochemical and structural features complicate classification and annotation of the rapidly growing number of identified homologs. Establishment of an adequate classification and unified nomenclature of meta- and paracaspases is especially important to avoid frequent confusion of these proteases with caspases - a tenacious misnomer that unfortunately does not appear to decline with time. This letter represents a consensus opinion of researchers studying different aspects of caspases, meta- and paracaspases in various organisms, ranging from microbes to plants and animals.",

author = "Minina, {Elena A.} and Jens Staal and Alvarez, {Vanina E.} and Berges, {John A.} and Ilana Berman-Frank and Rudi Beyaert and Bidle, {Kay D.} and Fr{\'e}d{\'e}ric Bornancin and Magali Casanova and Cazzulo, {Juan J.} and Choi, {Chang Jae} and Coll, {Nuria S.} and Dixit, {Vishva M.} and Marko Dolinar and Nicolas Fasel and Christiane Funk and Patrick Gallois and Kris Gevaert and Emilio Gutierrez-Beltran and Stephan Hailfinger and Marina Klemen{\v c}i{\v c} and Koonin, {Eugene V.} and Daniel Krappmann and Anna Linusson and Machado, {Maur{\'i}cio F.M.} and Frank Madeo and Megeney, {Lynn A.} and Moschou, {Panagiotis N.} and Mottram, {Jeremy C.} and Thomas Nystr{\"o}m and Osiewacz, {Heinz D.} and Overall, {Christopher M.} and Pandey, {Kailash C.} and J{\"u}rgen Ruland and Salvesen, {Guy S.} and Yigong Shi and Andrei Smertenko and Simon Stael and Jerry St{\aa}hlberg and Su{\'a}rez, {Mar{\'i}a Fernanda} and Margot Thome and Hannele Tuominen and {Van Breusegem}, Frank and {van der Hoorn}, {Renier A.L.} and Assaf Vardi and Boris Zhivotovsky and Eric Lam and Bozhkov, {Peter V.}",

note = "Funding Information: This work was supported by the Knut and Alice Wallenberg Foundation . We apologize to colleagues whose work has not been cited due to space limitations.",

year = "2020",

month = mar,

day = "5",

doi = "https://doi.org/10.1016/j.molcel.2019.12.020",

language = "American English",

volume = "77",

pages = "927--929",

journal = "Molecular Cell",

issn = "1097-2765",

publisher = "Cell Press",

number = "5",

}

Minina, EA, Staal, J, Alvarez, VE, Berges, JA, Berman-Frank, I, Beyaert, R, Bidle, KD, Bornancin, F, Casanova, M, Cazzulo, JJ, Choi, CJ, Coll, NS, Dixit, VM, Dolinar, M, Fasel, N, Funk, C, Gallois, P, Gevaert, K, Gutierrez-Beltran, E, Hailfinger, S, Klemenčič, M, Koonin, EV, Krappmann, D, Linusson, A, Machado, MFM, Madeo, F, Megeney, LA, Moschou, PN, Mottram, JC, Nyström, T, Osiewacz, HD, Overall, CM, Pandey, KC, Ruland, J, Salvesen, GS, Shi, Y, Smertenko, A, Stael, S, Ståhlberg, J, Suárez, MF, Thome, M, Tuominen, H, Van Breusegem, F, van der Hoorn, RAL, Vardi, A, Zhivotovsky, B, Lam, E & Bozhkov, PV 2020, 'Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases', Molecular Cell, vol. 77, no. 5, pp. 927-929. https://doi.org/10.1016/j.molcel.2019.12.020

TY - JOUR

T1 - Classification and Nomenclature of Metacaspases and Paracaspases

T2 - No More Confusion with Caspases

AU - Minina, Elena A.

AU - Staal, Jens

AU - Alvarez, Vanina E.

AU - Berges, John A.

AU - Berman-Frank, Ilana

AU - Beyaert, Rudi

AU - Bidle, Kay D.

AU - Bornancin, Frédéric

AU - Casanova, Magali

AU - Cazzulo, Juan J.

AU - Choi, Chang Jae

AU - Coll, Nuria S.

AU - Dixit, Vishva M.

AU - Dolinar, Marko

AU - Fasel, Nicolas

AU - Funk, Christiane

AU - Gallois, Patrick

AU - Gevaert, Kris

AU - Gutierrez-Beltran, Emilio

AU - Hailfinger, Stephan

AU - Klemenčič, Marina

AU - Koonin, Eugene V.

AU - Krappmann, Daniel

AU - Linusson, Anna

AU - Machado, Maurício F.M.

AU - Madeo, Frank

AU - Megeney, Lynn A.

AU - Moschou, Panagiotis N.

AU - Mottram, Jeremy C.

AU - Nyström, Thomas

AU - Osiewacz, Heinz D.

AU - Overall, Christopher M.

AU - Pandey, Kailash C.

AU - Ruland, Jürgen

AU - Salvesen, Guy S.

AU - Shi, Yigong

AU - Smertenko, Andrei

AU - Stael, Simon

AU - Ståhlberg, Jerry

AU - Suárez, María Fernanda

AU - Thome, Margot

AU - Tuominen, Hannele

AU - Van Breusegem, Frank

AU - van der Hoorn, Renier A.L.

AU - Vardi, Assaf

AU - Zhivotovsky, Boris

AU - Lam, Eric

AU - Bozhkov, Peter V.

N1 - Funding Information: This work was supported by the Knut and Alice Wallenberg Foundation . We apologize to colleagues whose work has not been cited due to space limitations.

PY - 2020/3/5

Y1 - 2020/3/5

N2 - Metacaspases and paracaspases are proteases that were first identified as containing a caspase-like structural fold (Uren et al., 2000). Like caspases, meta- and paracaspases are multifunctional proteins regulating diverse biological phenomena, such as aging, immunity, proteostasis and programmed cell death. The broad phylogenetic distribution of meta- and paracaspases across all kingdoms of life and large variation of their biochemical and structural features complicate classification and annotation of the rapidly growing number of identified homologs. Establishment of an adequate classification and unified nomenclature of meta- and paracaspases is especially important to avoid frequent confusion of these proteases with caspases - a tenacious misnomer that unfortunately does not appear to decline with time. This letter represents a consensus opinion of researchers studying different aspects of caspases, meta- and paracaspases in various organisms, ranging from microbes to plants and animals.

AB - Metacaspases and paracaspases are proteases that were first identified as containing a caspase-like structural fold (Uren et al., 2000). Like caspases, meta- and paracaspases are multifunctional proteins regulating diverse biological phenomena, such as aging, immunity, proteostasis and programmed cell death. The broad phylogenetic distribution of meta- and paracaspases across all kingdoms of life and large variation of their biochemical and structural features complicate classification and annotation of the rapidly growing number of identified homologs. Establishment of an adequate classification and unified nomenclature of meta- and paracaspases is especially important to avoid frequent confusion of these proteases with caspases - a tenacious misnomer that unfortunately does not appear to decline with time. This letter represents a consensus opinion of researchers studying different aspects of caspases, meta- and paracaspases in various organisms, ranging from microbes to plants and animals.

UR - http://www.scopus.com/inward/record.url?scp=85080130145&partnerID=8YFLogxK

U2 - https://doi.org/10.1016/j.molcel.2019.12.020

DO - https://doi.org/10.1016/j.molcel.2019.12.020

M3 - Letter

C2 - 32142688

SN - 1097-2765

VL - 77

SP - 927

EP - 929

JO - Molecular Cell

JF - Molecular Cell

IS - 5

ER -

Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases

Abstract

All Science Journal Classification (ASJC) codes

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