Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID -19

Christophe Guervilly; Stephane Burtey; Florence Sabatier; Raphaël Cauchois; Guillaume Lano; Evelyne Abdili; Florence Daviet; Laurent Arnaud; Philippe Brunet; Sami Hraiech; Noémie Jourde-Chiche; Marie Koubi; Romaric Lacroix; Léa Pietri; Yaël Berda; Thomas Robert; Clara Degioanni; Mélanie Velier; Laurent Papazian; Gilles Kaplanski; Françoise DIgnat-George

doi:10.1093/infdis/jiaa528

Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID -19

Christophe Guervilly, Stephane Burtey, Florence Sabatier, Raphaël Cauchois, Guillaume Lano, Evelyne Abdili, Florence Daviet, Laurent Arnaud, Philippe Brunet, Sami Hraiech, Noémie Jourde-Chiche, Marie Koubi, Romaric Lacroix, Léa Pietri, Yaël Berda, Thomas Robert, Clara Degioanni, Mélanie Velier, Laurent Papazian, Gilles KaplanskiFrançoise DIgnat-George

Research output: Contribution to journal › Article › peer-review

Abstract

Beside the commonly described pulmonary expression of the coronavirus disease 2019 (COVID-19), major vascular events have been reported. The objective of this study was to investigate whether increased levels of circulating endothelial cells (CECs) might be associated with severe forms of COVID-19. Ninety-nine patients with COVID-19 were enrolled in this retrospective study. Patients in the intensive care units (ICU) had significantly higher CEC counts than non-ICU patients and the extent of endothelial injury was correlated with putative markers of disease severity and inflammatory cytokines. Together, these data provide in vivo evidence that endothelial injury is a key feature of COVID-19.

Original language	English
Pages (from-to)	1789-1793
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	222
Issue number	11
DOIs	https://doi.org/10.1093/infdis/jiaa528
State	Published - 1 Dec 2020
Externally published	Yes

Keywords

COVID-19
circulating endothelial cells
endothelial injury

All Science Journal Classification (ASJC) codes

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/infdis/jiaa528

Cite this

Guervilly, C., Burtey, S., Sabatier, F., Cauchois, R., Lano, G., Abdili, E., Daviet, F., Arnaud, L., Brunet, P., Hraiech, S., Jourde-Chiche, N., Koubi, M., Lacroix, R., Pietri, L., Berda, Y., Robert, T., Degioanni, C., Velier, M., Papazian, L., ... DIgnat-George, F. (2020). Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID -19. Journal of Infectious Diseases, 222(11), 1789-1793. https://doi.org/10.1093/infdis/jiaa528

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title = "Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID -19",

abstract = "Beside the commonly described pulmonary expression of the coronavirus disease 2019 (COVID-19), major vascular events have been reported. The objective of this study was to investigate whether increased levels of circulating endothelial cells (CECs) might be associated with severe forms of COVID-19. Ninety-nine patients with COVID-19 were enrolled in this retrospective study. Patients in the intensive care units (ICU) had significantly higher CEC counts than non-ICU patients and the extent of endothelial injury was correlated with putative markers of disease severity and inflammatory cytokines. Together, these data provide in vivo evidence that endothelial injury is a key feature of COVID-19.",

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author = "Christophe Guervilly and Stephane Burtey and Florence Sabatier and Rapha{\"e}l Cauchois and Guillaume Lano and Evelyne Abdili and Florence Daviet and Laurent Arnaud and Philippe Brunet and Sami Hraiech and No{\'e}mie Jourde-Chiche and Marie Koubi and Romaric Lacroix and L{\'e}a Pietri and Ya{\"e}l Berda and Thomas Robert and Clara Degioanni and M{\'e}lanie Velier and Laurent Papazian and Gilles Kaplanski and Fran{\c c}oise DIgnat-George",

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year = "2020",

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doi = "10.1093/infdis/jiaa528",

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Guervilly, C, Burtey, S, Sabatier, F, Cauchois, R, Lano, G, Abdili, E, Daviet, F, Arnaud, L, Brunet, P, Hraiech, S, Jourde-Chiche, N, Koubi, M, Lacroix, R, Pietri, L, Berda, Y, Robert, T, Degioanni, C, Velier, M, Papazian, L, Kaplanski, G & DIgnat-George, F 2020, 'Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID -19', Journal of Infectious Diseases, vol. 222, no. 11, pp. 1789-1793. https://doi.org/10.1093/infdis/jiaa528

TY - JOUR

T1 - Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID -19

AU - Guervilly, Christophe

AU - Burtey, Stephane

AU - Sabatier, Florence

AU - Cauchois, Raphaël

AU - Lano, Guillaume

AU - Abdili, Evelyne

AU - Daviet, Florence

AU - Arnaud, Laurent

AU - Brunet, Philippe

AU - Hraiech, Sami

AU - Jourde-Chiche, Noémie

AU - Koubi, Marie

AU - Lacroix, Romaric

AU - Pietri, Léa

AU - Berda, Yaël

AU - Robert, Thomas

AU - Degioanni, Clara

AU - Velier, Mélanie

AU - Papazian, Laurent

AU - Kaplanski, Gilles

AU - DIgnat-George, Françoise

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Beside the commonly described pulmonary expression of the coronavirus disease 2019 (COVID-19), major vascular events have been reported. The objective of this study was to investigate whether increased levels of circulating endothelial cells (CECs) might be associated with severe forms of COVID-19. Ninety-nine patients with COVID-19 were enrolled in this retrospective study. Patients in the intensive care units (ICU) had significantly higher CEC counts than non-ICU patients and the extent of endothelial injury was correlated with putative markers of disease severity and inflammatory cytokines. Together, these data provide in vivo evidence that endothelial injury is a key feature of COVID-19.

AB - Beside the commonly described pulmonary expression of the coronavirus disease 2019 (COVID-19), major vascular events have been reported. The objective of this study was to investigate whether increased levels of circulating endothelial cells (CECs) might be associated with severe forms of COVID-19. Ninety-nine patients with COVID-19 were enrolled in this retrospective study. Patients in the intensive care units (ICU) had significantly higher CEC counts than non-ICU patients and the extent of endothelial injury was correlated with putative markers of disease severity and inflammatory cytokines. Together, these data provide in vivo evidence that endothelial injury is a key feature of COVID-19.

KW - COVID-19

KW - circulating endothelial cells

KW - endothelial injury

UR - http://www.scopus.com/inward/record.url?scp=85092484402&partnerID=8YFLogxK

U2 - 10.1093/infdis/jiaa528

DO - 10.1093/infdis/jiaa528

M3 - مقالة

C2 - 32812049

SN - 0022-1899

VL - 222

SP - 1789

EP - 1793

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 11

ER -

Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID -19

Abstract

Keywords

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UN SDGs

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