@article{911330eca61343b499f9bb28e67c3616,
title = "Circadian Influences of Diet on the Microbiome and Immunity",
abstract = "Host circadian rhythmicity and the timing of feeding are increasingly recognized to cross-regulate and entrain each other, and may play crucial roles in regulating multiple physiological functions including host immunity and metabolic health. Of relevance, these circadian diet-immune interactions may be modulated by the gut microbiota. We review current knowledge linking the circadian clock and dietary timing to host immune-microbiota interactions, exemplifying how this axis may impact on host immunity in health and in a variety of immuneme-diated diseases. We also discuss current challenges in reaching mechanistic insights regarding the functions of the diurnally shifting diet-microbiome-host immune axis. We highlight the possible implications of circadian reprogramming by dietary timing patterns as a future intervention to modulate a variety of immune-related diseases.",
author = "Danping Zheng and Karina Ratiner and Eran Elinav",
note = "We thank members of the laboratory of E.E. for discussions, and we apologize to authors whose work could not be cited because of space constraints. D.Z. is the recipient of the European Crohn's and Colitis Organization (ECCO) Fellowship, and is supported by the Ke Lin Program of the First Affiliated Hospital, Sun Yat-sen University. E.E. is supported by Yael and Rami Ungar, the Leona M. and Harry B. Helmsley Charitable Trust, Adelis Foundation, Pearl Welinsky Merlo Scientific Progress Research Fund, Lawrence and Sandra Post Family Foundation, Daniel Morris Trust, Park Avenue Charitable Fund, Hanna and Dr Ludwik Wallach Cancer Research Fund, Howard and Nancy Marks Charitable Fund, Aliza Moussaieff, Estate of Malka Moskowitz, Estate of Myron H. Ackerman, Estate of Bernard Bishin for the WIS-Clalit Program, Donald and Susan Schwarz, The V. R. Schwartz Research Fellow Chair, and by grants from the European Research Council, Israel Science Foundation, Israel Ministry of Science and Technology, Israel Ministry of Health, the Helmholtz Foundation, Else Kroener Fresenius Foundation, Garvan Institute, European Crohn{\textquoteright}s and Colitis Organization, Deutsch–Israelische Projektkooperation, and the Wellcome Trust. E.E. is the incumbent of the Sir Marc and Lady Tania Feldmann Professorial Chair, a senior fellow of the Canadian Institute of Advanced Research (CIFAR), and an international scholar of the Bill and Melinda Gates Foundation and the Howard Hughes Medical Institute (HHMI).",
year = "2020",
month = jun,
doi = "https://doi.org/10.1016/j.it.2020.04.005",
language = "الإنجليزيّة",
volume = "41",
pages = "512--530",
journal = "Trends in Immunology",
issn = "1471-4906",
publisher = "Elsevier Ltd.",
number = "6",
}