Circadian Influences of Diet on the Microbiome and Immunity

Danping Zheng, Karina Ratiner, Eran Elinav

Research output: Contribution to journalReview articlepeer-review


Host circadian rhythmicity and the timing of feeding are increasingly recognized to cross-regulate and entrain each other, and may play crucial roles in regulating multiple physiological functions including host immunity and metabolic health. Of relevance, these circadian diet-immune interactions may be modulated by the gut microbiota. We review current knowledge linking the circadian clock and dietary timing to host immune-microbiota interactions, exemplifying how this axis may impact on host immunity in health and in a variety of immuneme-diated diseases. We also discuss current challenges in reaching mechanistic insights regarding the functions of the diurnally shifting diet-microbiome-host immune axis. We highlight the possible implications of circadian reprogramming by dietary timing patterns as a future intervention to modulate a variety of immune-related diseases.

Original languageEnglish
Pages (from-to)512-530
Number of pages19
JournalTrends in Immunology
Issue number6
Early online date28 Apr 2020
StatePublished - Jun 2020


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