Circadian control of mitochondrial dynamics and functions

Saar Ezagouri; Gad Asher

doi:10.1016/j.cophys.2018.05.008

Circadian control of mitochondrial dynamics and functions

Saar Ezagouri, Gad Asher

Department of Biomolecular Sciences

Weizmann Institute of Science

Research output: Contribution to journal › Review article › peer-review

Abstract

Physiology and behavior in mammals is predominantly under circadian clock control. Circadian clocks are present in nearly every cell of the body and oscillate with a frequency of about 24 h in a self-sustained and cell autonomous manner. These clocks not only play a principal role in metabolic control but concurrently respond to a wide variety of metabolic cues. While various aspects of circadian regulation of metabolic functions have been extensively studied, our knowledge regarding circadian mitochondrial biology is just emerging. We review herein the current literature addressing circadian mitochondrial biology: from diurnal changes in mitochondrial make-up, through dynamics and functions. We will discuss as well potential mechanisms that are implicated in circadian control of mitochondrial biology in mammals.

Original language	English
Pages (from-to)	25-29
Number of pages	5
Journal	Current Opinion in Physiology
Volume	5
DOIs	https://doi.org/10.1016/j.cophys.2018.05.008
State	Published - Oct 2018

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title = "Circadian control of mitochondrial dynamics and functions",

abstract = "Physiology and behavior in mammals is predominantly under circadian clock control. Circadian clocks are present in nearly every cell of the body and oscillate with a frequency of about 24 h in a self-sustained and cell autonomous manner. These clocks not only play a principal role in metabolic control but concurrently respond to a wide variety of metabolic cues. While various aspects of circadian regulation of metabolic functions have been extensively studied, our knowledge regarding circadian mitochondrial biology is just emerging. We review herein the current literature addressing circadian mitochondrial biology: from diurnal changes in mitochondrial make-up, through dynamics and functions. We will discuss as well potential mechanisms that are implicated in circadian control of mitochondrial biology in mammals.",

author = "Saar Ezagouri and Gad Asher",

note = "We apologize to all colleagues whose work could not be cited due to space limitations. We are grateful to the members of the Asher lab for their valuable comments on the manuscript. G.A. is supported by the European Research Council (ERC-2017 CIRCOMMUNICATION 770869). G.A. is recipient of the EMBO young investigator award.",

year = "2018",

month = oct,

doi = "10.1016/j.cophys.2018.05.008",

language = "الإنجليزيّة",

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TY - JOUR

T1 - Circadian control of mitochondrial dynamics and functions

AU - Ezagouri, Saar

AU - Asher, Gad

N1 - We apologize to all colleagues whose work could not be cited due to space limitations. We are grateful to the members of the Asher lab for their valuable comments on the manuscript. G.A. is supported by the European Research Council (ERC-2017 CIRCOMMUNICATION 770869). G.A. is recipient of the EMBO young investigator award.

PY - 2018/10

Y1 - 2018/10

N2 - Physiology and behavior in mammals is predominantly under circadian clock control. Circadian clocks are present in nearly every cell of the body and oscillate with a frequency of about 24 h in a self-sustained and cell autonomous manner. These clocks not only play a principal role in metabolic control but concurrently respond to a wide variety of metabolic cues. While various aspects of circadian regulation of metabolic functions have been extensively studied, our knowledge regarding circadian mitochondrial biology is just emerging. We review herein the current literature addressing circadian mitochondrial biology: from diurnal changes in mitochondrial make-up, through dynamics and functions. We will discuss as well potential mechanisms that are implicated in circadian control of mitochondrial biology in mammals.

AB - Physiology and behavior in mammals is predominantly under circadian clock control. Circadian clocks are present in nearly every cell of the body and oscillate with a frequency of about 24 h in a self-sustained and cell autonomous manner. These clocks not only play a principal role in metabolic control but concurrently respond to a wide variety of metabolic cues. While various aspects of circadian regulation of metabolic functions have been extensively studied, our knowledge regarding circadian mitochondrial biology is just emerging. We review herein the current literature addressing circadian mitochondrial biology: from diurnal changes in mitochondrial make-up, through dynamics and functions. We will discuss as well potential mechanisms that are implicated in circadian control of mitochondrial biology in mammals.

U2 - 10.1016/j.cophys.2018.05.008

DO - 10.1016/j.cophys.2018.05.008

M3 - مقالة مرجعية

SN - 2468-8681

VL - 5

SP - 25

EP - 29

JO - Current Opinion in Physiology

JF - Current Opinion in Physiology

ER -

Circadian control of mitochondrial dynamics and functions

Abstract

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