Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety

Nina Dedic; Claudia Kuehne; Mira Jakovcevski; Jakob Hartmann; Andreas J. Genewsky; Karina S. Gomes; Elmira Anderzhanova; Max L. Poehlmann; Simon Chang; Adam Kolarz; Annette M. Vogl; Julien Dine; Michael W. Metzger; Bianca Schmid; Rafael C. Almada; Kerry J. Ressler; Carsten T. Wotjak; Valery Grinevich; Alon Chen; Mathias V. Schmidt; Wolfgang Wurst; Damian Refojo; Jan M. Deussing

doi:10.1038/s41593-018-0151-z

Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety

Nina Dedic
, Claudia Kuehne
, Mira Jakovcevski
, Jakob Hartmann
, Andreas J. Genewsky
, Karina S. Gomes
, Elmira Anderzhanova
, Max L. Poehlmann
, Simon Chang
, Adam Kolarz
, Annette M. Vogl
, Julien Dine
, Michael W. Metzger
, Bianca Schmid
, Rafael C. Almada
, Kerry J. Ressler
, Carsten T. Wotjak
, Valery Grinevich
, Alon Chen
, Mathias V. Schmidt

Wolfgang Wurst, Damian Refojo, Jan M. Deussing

Department of Brain Sciences

Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

Abstract

The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.

Original language	English
Pages (from-to)	803–807
Number of pages	8
Journal	Nature Neuroscience
Volume	21
Issue number	6
DOIs	https://doi.org/10.1038/s41593-018-0151-z
State	Published - Jun 2018

ASJC Scopus subject areas

General Neuroscience

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Dedic, N., Kuehne, C., Jakovcevski, M., Hartmann, J., Genewsky, A. J., Gomes, K. S., Anderzhanova, E., Poehlmann, M. L., Chang, S., Kolarz, A., Vogl, A. M., Dine, J., Metzger, M. W., Schmid, B., Almada, R. C., Ressler, K. J., Wotjak, C. T., Grinevich, V., Chen, A., ... Deussing, J. M. (2018). Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety. Nature Neuroscience, 21(6), 803–807. https://doi.org/10.1038/s41593-018-0151-z

@article{45aad55f1613409bbc99c4bba9aacaae,

title = "Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety",

abstract = "The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.",

author = "Nina Dedic and Claudia Kuehne and Mira Jakovcevski and Jakob Hartmann and Genewsky, \{Andreas J.\} and Gomes, \{Karina S.\} and Elmira Anderzhanova and Poehlmann, \{Max L.\} and Simon Chang and Adam Kolarz and Vogl, \{Annette M.\} and Julien Dine and Metzger, \{Michael W.\} and Bianca Schmid and Almada, \{Rafael C.\} and Ressler, \{Kerry J.\} and Wotjak, \{Carsten T.\} and Valery Grinevich and Alon Chen and Schmidt, \{Mathias V.\} and Wolfgang Wurst and Damian Refojo and Deussing, \{Jan M.\}",

note = "Publisher Copyright: {\textcopyright} 2018 The Author(s).",

year = "2018",

month = jun,

doi = "10.1038/s41593-018-0151-z",

language = "English",

volume = "21",

pages = "803–807",

journal = "Nature Neuroscience",

issn = "1097-6256",

publisher = "Nature Research",

number = "6",

}

Dedic, N, Kuehne, C, Jakovcevski, M, Hartmann, J, Genewsky, AJ, Gomes, KS, Anderzhanova, E, Poehlmann, ML, Chang, S, Kolarz, A, Vogl, AM, Dine, J, Metzger, MW, Schmid, B, Almada, RC, Ressler, KJ, Wotjak, CT, Grinevich, V, Chen, A, Schmidt, MV, Wurst, W, Refojo, D & Deussing, JM 2018, 'Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety', Nature Neuroscience, vol. 21, no. 6, pp. 803–807. https://doi.org/10.1038/s41593-018-0151-z

TY - JOUR

T1 - Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety

AU - Dedic, Nina

AU - Kuehne, Claudia

AU - Jakovcevski, Mira

AU - Hartmann, Jakob

AU - Genewsky, Andreas J.

AU - Gomes, Karina S.

AU - Anderzhanova, Elmira

AU - Poehlmann, Max L.

AU - Chang, Simon

AU - Kolarz, Adam

AU - Vogl, Annette M.

AU - Dine, Julien

AU - Metzger, Michael W.

AU - Schmid, Bianca

AU - Almada, Rafael C.

AU - Ressler, Kerry J.

AU - Wotjak, Carsten T.

AU - Grinevich, Valery

AU - Chen, Alon

AU - Schmidt, Mathias V.

AU - Wurst, Wolfgang

AU - Refojo, Damian

AU - Deussing, Jan M.

PY - 2018/6

Y1 - 2018/6

N2 - The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.

AB - The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.

UR - https://www.scopus.com/pages/publications/85047204795

U2 - 10.1038/s41593-018-0151-z

DO - 10.1038/s41593-018-0151-z

M3 - Article

SN - 1097-6256

VL - 21

SP - 803

EP - 807

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 6

ER -

Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety

Abstract

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