Chiral modulation of amyloid beta fibrillation and cytotoxicity by enantiomeric carbon dots

Ravit Malishev; Elad Arad; Susanta Kumar Bhunia; Shira Shaham-Niv; Sofiya Kolusheva; Ehud Gazit; Raz Jelinek

doi:10.1039/C8CC03235A

Chiral modulation of amyloid beta fibrillation and cytotoxicity by enantiomeric carbon dots

Ravit Malishev, Elad Arad, Susanta Kumar Bhunia, Shira Shaham-Niv, Sofiya Kolusheva, Ehud Gazit, Raz Jelinek

Ben-Gurion University of the Negev, Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Abstract

Enantiomeric carbon dots (C-dots) synthesized from l-lysine or d-lysine, modulate aggregation and cytotoxicity of amyloid beta-42 (Aβ42), the primary constituent of the amyloid plaques associated with Alzheimer's disease. In particular, l-Lys-C-dots dramatically remodeled Aβ42 secondary structure and fibril morphologies, as well as inhibited Aβ42 cytotoxicity and membrane interactions.

Original language	American English
Pages (from-to)	7762-7765
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	56
DOIs	https://doi.org/10.1039/C8CC03235A
State	Published - 1 Jan 2018

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/C8CC03235A

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title = "Chiral modulation of amyloid beta fibrillation and cytotoxicity by enantiomeric carbon dots",

abstract = "Enantiomeric carbon dots (C-dots) synthesized from l-lysine or d-lysine, modulate aggregation and cytotoxicity of amyloid beta-42 (Aβ42), the primary constituent of the amyloid plaques associated with Alzheimer's disease. In particular, l-Lys-C-dots dramatically remodeled Aβ42 secondary structure and fibril morphologies, as well as inhibited Aβ42 cytotoxicity and membrane interactions.",

author = "Ravit Malishev and Elad Arad and Bhunia, \{Susanta Kumar\} and Shira Shaham-Niv and Sofiya Kolusheva and Ehud Gazit and Raz Jelinek",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

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T1 - Chiral modulation of amyloid beta fibrillation and cytotoxicity by enantiomeric carbon dots

AU - Malishev, Ravit

AU - Arad, Elad

AU - Bhunia, Susanta Kumar

AU - Shaham-Niv, Shira

AU - Kolusheva, Sofiya

AU - Gazit, Ehud

AU - Jelinek, Raz

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Enantiomeric carbon dots (C-dots) synthesized from l-lysine or d-lysine, modulate aggregation and cytotoxicity of amyloid beta-42 (Aβ42), the primary constituent of the amyloid plaques associated with Alzheimer's disease. In particular, l-Lys-C-dots dramatically remodeled Aβ42 secondary structure and fibril morphologies, as well as inhibited Aβ42 cytotoxicity and membrane interactions.

AB - Enantiomeric carbon dots (C-dots) synthesized from l-lysine or d-lysine, modulate aggregation and cytotoxicity of amyloid beta-42 (Aβ42), the primary constituent of the amyloid plaques associated with Alzheimer's disease. In particular, l-Lys-C-dots dramatically remodeled Aβ42 secondary structure and fibril morphologies, as well as inhibited Aβ42 cytotoxicity and membrane interactions.

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U2 - 10.1039/C8CC03235A

DO - 10.1039/C8CC03235A

M3 - Article

C2 - 29947369

SN - 1359-7345

VL - 54

SP - 7762

EP - 7765

JO - Chemical Communications

JF - Chemical Communications

IS - 56

ER -

Chiral modulation of amyloid beta fibrillation and cytotoxicity by enantiomeric carbon dots

Abstract

All Science Journal Classification (ASJC) codes

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