Abstract
Provided are chimeric antigen receptor (CAR) molecules comprising an extracellular domain comprising an antigen binding domain, a transmembrane domain, and an intracellular signaling domain, wherein an affinity of said binding domain to said antigen is characterized by a KD higher than 150 nM. Also provided are isolated polynucleotides and nucleic acid constructs comprising same, cells transduced with same and methods of using same.
| Original language | American English |
|---|---|
| Patent number | US2019031759 |
| IPC | C07K 16/ 28 A I |
| Priority date | 30/04/15 |
| State | Published - 31 Jan 2019 |