TY - JOUR
T1 - Characterization of post-COVID syndromes by symptom cluster and time period up to 12 months post-infection
T2 - A systematic review and meta-analysis
AU - Kuodi, Paul
AU - Gorelik, Yanay
AU - Gausi, Blessing
AU - Bernstine, Tomer
AU - Edelstein, Michael
N1 - Publisher Copyright: © 2023 The Author(s)
PY - 2023/9
Y1 - 2023/9
N2 - Objectives: The objective of this study was to characterize post-COVID condition symptoms and symptom clusters, their duration, and prevalence. Methods: We conducted a systematic review and random-effects meta-analysis of studies reporting post-COVID-19 symptoms and clusters, respectively. We searched MEDLINE (via PubMed), Scopus, Web of Science, Science Direct, Google Scholar, EBSCOhost, EMBASE, PsycINFO, Cochrane Library, and Mednar for literature reporting on the post-COVID condition up to August 2022. Results: In the 76 included studies, we found that although most symptoms were reported less frequently 7-12 months after infection compared to earlier, over 20% of patients reported at least one post-COVID condition-compatible symptom. In the seven studies reporting post-COVID symptom clusters, neurological clustering was consistently identified, followed by cardiorespiratory and systemic/inflammatory. Conclusion: Post-COVID symptom clustering provides direction for research into the etiology, diagnosis, and management of post-COVID conditions. Studies reporting post-COVID symptom clusters remain rare due to the focus on individual symptom reporting. Studies on post-COVID symptom clusters should replace individual symptom reporting to accelerate our understanding of this emerging public health issue.
AB - Objectives: The objective of this study was to characterize post-COVID condition symptoms and symptom clusters, their duration, and prevalence. Methods: We conducted a systematic review and random-effects meta-analysis of studies reporting post-COVID-19 symptoms and clusters, respectively. We searched MEDLINE (via PubMed), Scopus, Web of Science, Science Direct, Google Scholar, EBSCOhost, EMBASE, PsycINFO, Cochrane Library, and Mednar for literature reporting on the post-COVID condition up to August 2022. Results: In the 76 included studies, we found that although most symptoms were reported less frequently 7-12 months after infection compared to earlier, over 20% of patients reported at least one post-COVID condition-compatible symptom. In the seven studies reporting post-COVID symptom clusters, neurological clustering was consistently identified, followed by cardiorespiratory and systemic/inflammatory. Conclusion: Post-COVID symptom clustering provides direction for research into the etiology, diagnosis, and management of post-COVID conditions. Studies reporting post-COVID symptom clusters remain rare due to the focus on individual symptom reporting. Studies on post-COVID symptom clusters should replace individual symptom reporting to accelerate our understanding of this emerging public health issue.
KW - COVID-19
KW - Long COVID
KW - Post-COVID condition
KW - SARS-CoV-2
UR - http://www.scopus.com/inward/record.url?scp=85160633472&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.ijid.2023.05.003
DO - https://doi.org/10.1016/j.ijid.2023.05.003
M3 - مقالة
C2 - 37150350
SN - 1201-9712
VL - 134
SP - 1
EP - 7
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
ER -