TY - JOUR
T1 - Characteristics of endovascular pneumococcal infections; a decade of nationwide surveillance study
AU - Kenig, Ariel
AU - Oster, Yonatan
AU - Cohen-Poradosu, Ronit
AU - Reisenberg, Klaris
AU - Wieder-Finesod, Anat
AU - Hershman-Sarafov, Mirit
AU - Oren, Ilana
AU - Weber, Gabriel
AU - Dagan, Ron
AU - Regev-Yochay, Gili
AU - Strahilevitz, Jacob
N1 - Funding Information: The IAIPD is part of the IsraNIP project. This study was supported in part by Wyeth (Pfizer), manufacturer of Prevnar 7 and Prevnar 13 [grant no. 0887Z1-4603]. Wyeth (Pfizer) had no role in designing the study, collecting the data, analyzing the data, interpreting the data, writing the report, or in the decision to submit the paper for publication. Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2022/11
Y1 - 2022/11
N2 - In order to characterize pneumococcal endovascular infection in the post-vaccination era, a retrospective nationwide study based on the Israeli Adult IPD database was conducted. Between 2010 and 2019, 0.6% (23 cases) of IPD cases were of endovascular type, occurring mainly in males (72.3%) with underlying medical conditions (78.2%). Additional pneumococcal source (10 patients) and concomitant infections were not uncommon. Penicillin and ceftriaxone susceptibility rates were 65.2% and 91.3%, respectively; 60.9% of the isolates were not covered by the pneumococcal conjugate vaccine. 21.7% of patients died during hospitalization. In conclusion, pneumococcal endovascular infections still carry significant morbidity and mortality.
AB - In order to characterize pneumococcal endovascular infection in the post-vaccination era, a retrospective nationwide study based on the Israeli Adult IPD database was conducted. Between 2010 and 2019, 0.6% (23 cases) of IPD cases were of endovascular type, occurring mainly in males (72.3%) with underlying medical conditions (78.2%). Additional pneumococcal source (10 patients) and concomitant infections were not uncommon. Penicillin and ceftriaxone susceptibility rates were 65.2% and 91.3%, respectively; 60.9% of the isolates were not covered by the pneumococcal conjugate vaccine. 21.7% of patients died during hospitalization. In conclusion, pneumococcal endovascular infections still carry significant morbidity and mortality.
KW - Endovascular infections
KW - Infective endocarditis
KW - Invasive pneumococcal disease
KW - Streptococcuspneumoniae
UR - http://www.scopus.com/inward/record.url?scp=85139170170&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/s10096-022-04500-w
DO - https://doi.org/10.1007/s10096-022-04500-w
M3 - Article
C2 - 36175812
SN - 0934-9723
VL - 41
SP - 1365
EP - 1370
JO - European Journal of Clinical Microbiology and Infectious Diseases
JF - European Journal of Clinical Microbiology and Infectious Diseases
IS - 11
ER -
