CHAPTER 1: Protein-Protein Interaction Interfaces and their Functional Implications

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Proteins must work together with other proteins to carry out most of their functions in the cell. In the complex biological environment, any correct interaction competes with a huge number of non-relevant macromolecular surfaces. In this chapter, I review the current knowledge on how the binding process occurs, what distinguishes correct binding from the endless numbers of available protein-surfaces and the contributing factors towards uniqueness of the binding interface, and put these into perspective with the different types of protein-protein interactions found in nature. While the gained knowledge provides only averages, it is sufficiently good for the design of new protein-protein interactions, which has become more successful in recent years.

Original languageEnglish
Title of host publicationProtein Degradation with New Chemical Modalities
Subtitle of host publicationSuccessful Strategies in Drug Discovery and Chemical Biology
EditorsSiddhartha Roy, Haian Fu
PublisherRoyal Society of Chemistry
Chapter1
Pages1-24
Number of pages24
Edition78
ISBN (Electronic)9781788011877, 9781788015479, 9781788016865, 9781788018012, 9781788018760
DOIs
StatePublished - 14 Nov 2020

Publication series

NameRSC Drug Discovery Series
Number78
Volume2021-January
ISSN (Print)2041-3203

All Science Journal Classification (ASJC) codes

  • Drug Discovery

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