TY - JOUR
T1 - Cellular Senescence
T2 - Defining a Path Forward
AU - Gorgoulis, Vassilis
AU - Adams, Peter D.
AU - Alimonti, Andrea
AU - Bennett, Dorothy C.
AU - Bischof, Oliver
AU - Bishop, Cleo
AU - Campisi, Judith
AU - Collado, Manuel
AU - Evangelou, Konstantinos
AU - Ferbeyre, Gerardo
AU - Gil, Jesus
AU - Hara, Eiji
AU - Krizhanovsky, Valery
AU - Jurk, Diana
AU - Maier, Andrea B.
AU - Narita, Masashi
AU - Niedernhofer, Laura
AU - Passos, Joao F.
AU - Robbins, Paul D.
AU - Schmitt, Clemens A.
AU - Sedivy, John
AU - Vougas, Konstantinos
AU - von Zglinicki, Thomas
AU - Zhou, Daohong
AU - Serrano, Manuel
AU - Demaria, Marco
N1 - We would like to thank Nikolaos Kastrinakis, Panagiotis V.S. Vasileiou, Gkikas Magiorkinis, Eleni Fitsiou, and Michela Borghesan for their valuable support to this work. We apologize in advance that, for reason of space, we have omitted the citations of relevant papers and reviews. M.D. is funded by the Dutch Cancer Foundation, Netherlands (grant ID 10989). V.G., K.E., and K.V. were financially supported by the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grants agreement no. 722729 (SYNTRAIN); the Welfare Foundation for Social & Cultural Sciences (KIKPE), Greece; the KIKPE Foundation, Athens, Greece; Pentagon Biotechnology, UK; DeepMed IO, UK; grant no. 775 from the Hellenic Foundation for Research and Innovation (HFRI); and NKUA-SARG grants 70/3/9816, 70/3/12128, and 70/3/15603. M.S.: is funded by the IRB and by grants from the Spanish Ministry of Economy co-funded by the European Regional Development Fund (ERDF) (SAF2013-48256-R), the European Research Council (ERC-2014-AdG/669622), and “laCaixa” Foundation.
PY - 2019/10/31
Y1 - 2019/10/31
N2 - Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly. Thus, the accurate detection of senescent cells, especially in vivo, is essential. Here, we present a consensus from the International Cell Senescence Association (ICSA), defining and discussing key cellular and molecular features of senescence and offering recommendations on how to use them as biomarkers. We also present a resource tool to facilitate the identification of genes linked with senescence, SeneQuest (available at http://Senequest.net). Lastly, we propose an algorithm to accurately assess and quantify senescence, both in cultured cells and in vivo.
AB - Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly. Thus, the accurate detection of senescent cells, especially in vivo, is essential. Here, we present a consensus from the International Cell Senescence Association (ICSA), defining and discussing key cellular and molecular features of senescence and offering recommendations on how to use them as biomarkers. We also present a resource tool to facilitate the identification of genes linked with senescence, SeneQuest (available at http://Senequest.net). Lastly, we propose an algorithm to accurately assess and quantify senescence, both in cultured cells and in vivo.
UR - http://www.scopus.com/inward/record.url?scp=85074054595&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.cell.2019.10.005
DO - https://doi.org/10.1016/j.cell.2019.10.005
M3 - مقالة مرجعية
SN - 0092-8674
VL - 179
SP - 813
EP - 827
JO - Cell
JF - Cell
IS - 4
ER -