Cells, drugs and NMR

Gregg Siegal, Philipp Selenko

Research output: Contribution to journalArticlepeer-review

Abstract

Nuclear magnetic resonance (NMR) spectroscopy is a versatile tool for investigating cellular structures and their compositions. While in vivo and whole-cell NMR have a long tradition in cell-based approaches, high-resolution in-cell NMR spectroscopy is a new addition to these methods. In recent years, technological advancements in multiple areas provided converging benefits for cellular MR applications, especially in terms of robustness, reproducibility and physiological relevance. Here, we review the use of cellular NMR methods for drug discovery purposes in academia and industry. Specifically, we discuss how developments in NMR technologies such as miniaturized bioreactors and flow-probe perfusion systems have helped to consolidate NMR’s role in cell-based drug discovery efforts.
Original languageEnglish
Pages (from-to)202-212
Number of pages11
JournalJOURNAL OF MAGNETIC RESONANCE
Volume306
DOIs
StatePublished - Sep 2019

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Nuclear and High Energy Physics
  • Condensed Matter Physics

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