Cell types of origin of the cell-free transcriptome

doi:https://doi.org/10.1038/s41587-021-01188-9

Cell types of origin of the cell-free transcriptome

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Abstract

Cell-free RNA from liquid biopsies can be analyzed to determine disease tissue of origin. We extend this concept to identify cell types of origin using the Tabula Sapiens transcriptomic cell atlas as well as individual tissue transcriptomic cell atlases in combination with the Human Protein Atlas RNA consensus dataset. We define cell type signature scores, which allow the inference of cell types that contribute to cell-free RNA for a variety of diseases.

Original language	English
Pages (from-to)	855-+
Number of pages	27
Journal	Nature biotechnology
Volume	40
Issue number	6
DOIs	https://doi.org/10.1038/s41587-021-01188-9
State	Published - Jun 2022
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology
Molecular Medicine
Biomedical Engineering

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https://doi.org/10.1038/s41587-021-01188-9

Cite this

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title = "Cell types of origin of the cell-free transcriptome",

abstract = "Cell-free RNA from liquid biopsies can be analyzed to determine disease tissue of origin. We extend this concept to identify cell types of origin using the Tabula Sapiens transcriptomic cell atlas as well as individual tissue transcriptomic cell atlases in combination with the Human Protein Atlas RNA consensus dataset. We define cell type signature scores, which allow the inference of cell types that contribute to cell-free RNA for a variety of diseases.",

author = "Vorperian, {Sevahn K.} and Moufarrej, {Mira N.} and Tony Wyss-Coray and Wu, {Sean M.} and Albert Wu and Sonnenburg, {Justin L.} and Relman, {David A.} and Jeremy Reiter and Kristy Red-Horse and Rando, {Thomas A.} and Patricia Nguyen and Kuo, {Christin S.} and Kim, {Seung K.} and Juliana Idoyaga and Huang, {Kerwyn Casey} and Huang, {Franklin W.} and Giudice, {Linda C.} and Clarke, {Michael F.} and Beachy, {Philip A.} and Nir Yosef",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2022. corrected publication 2022.",

year = "2022",

month = jun,

doi = "https://doi.org/10.1038/s41587-021-01188-9",

language = "الإنجليزيّة",

volume = "40",

pages = "855--+",

journal = "Nature biotechnology",

issn = "1087-0156",

publisher = "Nature Research",

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TY - JOUR

T1 - Cell types of origin of the cell-free transcriptome

AU - Vorperian, Sevahn K.

AU - Moufarrej, Mira N.

AU - Wyss-Coray, Tony

AU - Wu, Sean M.

AU - Wu, Albert

AU - Sonnenburg, Justin L.

AU - Relman, David A.

AU - Reiter, Jeremy

AU - Red-Horse, Kristy

AU - Rando, Thomas A.

AU - Nguyen, Patricia

AU - Kuo, Christin S.

AU - Kim, Seung K.

AU - Idoyaga, Juliana

AU - Huang, Kerwyn Casey

AU - Huang, Franklin W.

AU - Giudice, Linda C.

AU - Clarke, Michael F.

AU - Beachy, Philip A.

AU - Yosef, Nir

PY - 2022/6

Y1 - 2022/6

N2 - Cell-free RNA from liquid biopsies can be analyzed to determine disease tissue of origin. We extend this concept to identify cell types of origin using the Tabula Sapiens transcriptomic cell atlas as well as individual tissue transcriptomic cell atlases in combination with the Human Protein Atlas RNA consensus dataset. We define cell type signature scores, which allow the inference of cell types that contribute to cell-free RNA for a variety of diseases.

AB - Cell-free RNA from liquid biopsies can be analyzed to determine disease tissue of origin. We extend this concept to identify cell types of origin using the Tabula Sapiens transcriptomic cell atlas as well as individual tissue transcriptomic cell atlases in combination with the Human Protein Atlas RNA consensus dataset. We define cell type signature scores, which allow the inference of cell types that contribute to cell-free RNA for a variety of diseases.

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U2 - https://doi.org/10.1038/s41587-021-01188-9

DO - https://doi.org/10.1038/s41587-021-01188-9

M3 - مقالة

C2 - 35132263

SN - 1087-0156

VL - 40

SP - 855-+

JO - Nature biotechnology

JF - Nature biotechnology

IS - 6

ER -

Cell types of origin of the cell-free transcriptome

Abstract

All Science Journal Classification (ASJC) codes

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