Cell size sensinga one-dimensional solution for a three-dimensional problem?

Ida Rishal, Mike Fainzilber

Research output: Contribution to journalArticlepeer-review


Individual cell types have characteristic sizes, suggesting that size sensing mechanisms may coordinate transcription, translation, and metabolism with cell growth rates. Two types of size-sensing mechanisms have been proposed: spatial sensing of the location or dimensions of a signal, subcellular structure or organelle; or titration-based sensing of the intracellular concentrations of key regulators. Here we propose that size sensing in animal cells combines both titration and spatial sensing elements in a dynamic mechanism whereby microtubule motor-dependent localization of RNA encoding importin β1 and mTOR, coupled with regulated local protein synthesis, enable cytoskeleton length sensing for cell growth regulation.

Original languageEnglish
Article number36
Number of pages7
JournalBMC Biology
Issue number1
StatePublished - 29 Apr 2019

All Science Journal Classification (ASJC) codes

  • General Biochemistry,Genetics and Molecular Biology
  • Ecology, Evolution, Behavior and Systematics
  • Structural Biology
  • Physiology
  • General Agricultural and Biological Sciences
  • Biotechnology
  • Plant Science
  • Cell Biology
  • Developmental Biology


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