TY - JOUR
T1 - Cell cluster migration
T2 - Connecting experiments with physical models
AU - Gopinathan, Ajay
AU - Gov, Nir S.
N1 - AG was partially supported by National Science Foundation NSF grant DMS-1616926 and the NSF-CREST: Center for Cellular and Bio-molecular Machines at UC Merced (NSF-HRD-1547848). AG would also like to acknowledge the hospitality of the Aspen Center for Physics, which is supported by National Science Foundation grant PHY-1607611, where some of this work was done.
PY - 2019/9
Y1 - 2019/9
N2 - In multi-cellular organisms, the migration of cohesive clusters of cells containing many individual cells is a common occurrence. Examples include the migration of cells during processes such as the development of the embryo, wound healing, immune response, and the spread of cancer. The migration process depends not only on the traction forces applied by the cluster on its surroundings, in order to move, but also on the viscoelastic properties of both the surrounding matrix and the migrating cellular cluster. Characterizing the viscoelastic properties of the cluster, its environment and the forces within the cluster, in great detail, is difficult both invitro and certainly in-vivo. We review here several examples where theoretical studies using simplified models can be used to gain insights into the basic underlying mechanisms that control the cellular migration patterns.
AB - In multi-cellular organisms, the migration of cohesive clusters of cells containing many individual cells is a common occurrence. Examples include the migration of cells during processes such as the development of the embryo, wound healing, immune response, and the spread of cancer. The migration process depends not only on the traction forces applied by the cluster on its surroundings, in order to move, but also on the viscoelastic properties of both the surrounding matrix and the migrating cellular cluster. Characterizing the viscoelastic properties of the cluster, its environment and the forces within the cluster, in great detail, is difficult both invitro and certainly in-vivo. We review here several examples where theoretical studies using simplified models can be used to gain insights into the basic underlying mechanisms that control the cellular migration patterns.
U2 - 10.1016/j.semcdb.2018.09.009
DO - 10.1016/j.semcdb.2018.09.009
M3 - مقالة مرجعية
SN - 1084-9521
VL - 93
SP - 77
EP - 86
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
ER -