@article{9ae6fa5673d9469caf8184ff05df1003,
title = "CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice",
abstract = "Immune mechanisms are known to control the pathogenesis of atherosclerosis. However, the exact role of DCs, which are essential for priming of immune responses, remains elusive. We have shown here that the DC-derived chemokine CCL17 is present in advanced human and mouse atherosclerosis and that CCL17 + DCs accumulate in atherosclerotic lesions. In atherosclerosis-prone mice, Ccl17 deficiency entailed a reduction of atherosclerosis, which was dependent on Tregs. Expression of CCL17 by DCs limited the expansion of Tregs by restricting their maintenance and precipitated atherosclerosis in a mechanism conferred by T cells. Conversely, a blocking antibody specific for CCL17 expanded Tregs and reduced atheroprogression. Our data identify DC-derived CCL17 as a central regulator of Treg homeostasis, implicate DCs and their effector functions in atherogenesis, and suggest that CCL17 might be a target for vascular therapy.",
author = "Christian Weber and Svenja Meiler and Yvonne D{\"o}ring and Miriam Koch and Maik Drechsler and Megens, \{Remco T.A.\} and Zuzanna Rowinska and Kiril Bidzhekov and Caroline Fecher and Eliana Ribechini and \{Van Zandvoort\}, \{Marc A.M.J.\} and Binder, \{Christoph J.\} and Ivett Jelinek and Mihail Hristov and Louis Boon and Steffen Jung and Thomas Korn and Lutz, \{Manfred B.\} and Irmgard F{\"o}rster and Martin Zenke and Thomas Hieronymus and Tobias Junt and Alma Zernecke",
note = "Interdisciplinary Centre for Clinical Research Aachen; Deutsche Forschungsgemeinschaft [FOR809, WE1913/11-1, WE1913/11-2, SFB704 TPA1, ZE827/1-1, ZE827/1-2, Sr:13688 TPA12, ZE827/4-1]We thank X. Ren for help with experiments and M. Garbe, S. Roubrocks, M. Schott, and S. Wilbertz for excellent technical assistance. This work was supported by the Interdisciplinary Centre for Clinical Research Aachen (to A. Zernecke) and the Deutsche Forschungsgemeinschaft (FOR809, WE1913/11-1 and 11-2 to C. Weber; SFB704 TPA1 to I. Forster; ZE827/1-1 to A. Zernecke, T. Hieronymus, and M. Zenke; ZE827/1-2 to A. Zernecke and M. Zenke; Sr:13688 TPA12 and ZE827/4-1 to A. Zernecke).",
year = "2011",
month = jul,
doi = "10.1172/JCI44925",
language = "الإنجليزيّة",
volume = "121",
pages = "2898--2910",
journal = "Journal of Clinical Investigation",
issn = "0021-9738",
publisher = "American Society for Clinical Investigation",
number = "7",
}