Cation/proton antiporters: novel structure-driven pharmaceutical opportunities

Gal Masrati; Amit Kessel; Nir Ben-Tal

doi:10.1016/j.tips.2023.02.006

Cation/proton antiporters: novel structure-driven pharmaceutical opportunities

Gal Masrati, Amit Kessel, Nir Ben-Tal

Tel Aviv University

Research output: Contribution to journal › Short survey › peer-review

Abstract

Cation/proton antiporters (CPAs) regulate cells’ salt concentration and pH. Their malfunction is associated with a range of human pathologies, yet only a handful of CPA-targeting therapeutics are presently in clinical development. Here, we discuss how recently published mammalian protein structures and emerging computational technologies may help to bridge this gap.

Original language	English
Pages (from-to)	258-262
Number of pages	5
Journal	Trends in Pharmacological Sciences
Volume	44
Issue number	5
DOIs	https://doi.org/10.1016/j.tips.2023.02.006
State	Published - May 2023

Keywords

cation/proton antiporters
computational biology
pharmacology

All Science Journal Classification (ASJC) codes

Toxicology
Pharmacology

Access to Document

10.1016/j.tips.2023.02.006

Cite this

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AB - Cation/proton antiporters (CPAs) regulate cells’ salt concentration and pH. Their malfunction is associated with a range of human pathologies, yet only a handful of CPA-targeting therapeutics are presently in clinical development. Here, we discuss how recently published mammalian protein structures and emerging computational technologies may help to bridge this gap.

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Cation/proton antiporters: novel structure-driven pharmaceutical opportunities

Abstract

Keywords

All Science Journal Classification (ASJC) codes

Access to Document

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