Case report of increased exposure to antiretrovirals following sleeve gastrectomy

Sarah Israel; Hila Elinav; Ram Elazary; Daniel Porat; Roni Gibori; Arik Dahan; Carmil Azran; Ehud Horwitz

doi:10.1128/AAC.02453-19

Case report of increased exposure to antiretrovirals following sleeve gastrectomy

Sarah Israel, Hila Elinav, Ram Elazary, Daniel Porat, Roni Gibori, Arik Dahan, Carmil Azran, Ehud Horwitz

Department of Clinical Biochemistry and Pharmacology

Ben-Gurion University of the Negev

Research output: Contribution to journal › Article › peer-review

Abstract

Bariatric surgery is increasingly performed in morbidly obese HIV patients. Limited data exist regarding antiretroviral drug exposure after bariatric surgery. We report a case of a morbidly obese HIV patient who underwent sleeve gastrectomy. Abacavir, lamivudine, and dolutegravir therapeutic drug monitoring was performed at several time points pre- and postsurgery. Significantly increased levels were measured, particularly for abacavir, whose levels increased ~12-fold. Several mechanistic explanations for these findings are discussed.

Original language	American English
Article number	e02453-19
Journal	Antimicrobial Agents and Chemotherapy
Volume	64
Issue number	4
DOIs	https://doi.org/10.1128/AAC.02453-19
State	Published - 1 Jan 2020

Keywords

Antiretrovirals
Bariatric surgery
Obesity
Sleeve gastrectomy

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.02453-19

Cite this

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title = "Case report of increased exposure to antiretrovirals following sleeve gastrectomy",

abstract = "Bariatric surgery is increasingly performed in morbidly obese HIV patients. Limited data exist regarding antiretroviral drug exposure after bariatric surgery. We report a case of a morbidly obese HIV patient who underwent sleeve gastrectomy. Abacavir, lamivudine, and dolutegravir therapeutic drug monitoring was performed at several time points pre- and postsurgery. Significantly increased levels were measured, particularly for abacavir, whose levels increased ~12-fold. Several mechanistic explanations for these findings are discussed.",

keywords = "Antiretrovirals, Bariatric surgery, Obesity, Sleeve gastrectomy",

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AU - Israel, Sarah

AU - Elinav, Hila

AU - Elazary, Ram

AU - Porat, Daniel

AU - Gibori, Roni

AU - Dahan, Arik

AU - Azran, Carmil

AU - Horwitz, Ehud

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Bariatric surgery is increasingly performed in morbidly obese HIV patients. Limited data exist regarding antiretroviral drug exposure after bariatric surgery. We report a case of a morbidly obese HIV patient who underwent sleeve gastrectomy. Abacavir, lamivudine, and dolutegravir therapeutic drug monitoring was performed at several time points pre- and postsurgery. Significantly increased levels were measured, particularly for abacavir, whose levels increased ~12-fold. Several mechanistic explanations for these findings are discussed.

AB - Bariatric surgery is increasingly performed in morbidly obese HIV patients. Limited data exist regarding antiretroviral drug exposure after bariatric surgery. We report a case of a morbidly obese HIV patient who underwent sleeve gastrectomy. Abacavir, lamivudine, and dolutegravir therapeutic drug monitoring was performed at several time points pre- and postsurgery. Significantly increased levels were measured, particularly for abacavir, whose levels increased ~12-fold. Several mechanistic explanations for these findings are discussed.

KW - Antiretrovirals

KW - Bariatric surgery

KW - Obesity

KW - Sleeve gastrectomy

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DO - 10.1128/AAC.02453-19

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SN - 0066-4804

VL - 64

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 4

M1 - e02453-19

ER -

Case report of increased exposure to antiretrovirals following sleeve gastrectomy

Abstract

Keywords

All Science Journal Classification (ASJC) codes

UN SDGs

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