Cascade Pd(ii)-catalyzed Wacker lactonization-Heck reaction: Rapid assembly of spiranoid lactones

Ghassan Albarghouti; Ramesh Kotikalapudi; David Lankri; Viviana Valerio; Dmitry Tsvelikhovsky

doi:10.1039/c5cc09923d

Cascade Pd(ii)-catalyzed Wacker lactonization-Heck reaction: Rapid assembly of spiranoid lactones

Ghassan Albarghouti, Ramesh Kotikalapudi, David Lankri, Viviana Valerio, Dmitry Tsvelikhovsky

School of Pharmacy

The Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

Abstract

An unprecedented Pd-catalyzed cascade Wacker-Heck lactonization-cyclization sequence is reported. The process provides a facile approach to bi- and tricyclic spiranoid lactones in good yields. The reaction shows general substrate scope and a broad functional group tolerability. In addition, a rare 4-exo trig Heck-type cyclization is demonstrated.

Original language	English
Pages (from-to)	3095-3098
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	15
DOIs	https://doi.org/10.1039/c5cc09923d
State	Published - 2016

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

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10.1039/c5cc09923d

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title = "Cascade Pd(ii)-catalyzed Wacker lactonization-Heck reaction: Rapid assembly of spiranoid lactones",

abstract = "An unprecedented Pd-catalyzed cascade Wacker-Heck lactonization-cyclization sequence is reported. The process provides a facile approach to bi- and tricyclic spiranoid lactones in good yields. The reaction shows general substrate scope and a broad functional group tolerability. In addition, a rare 4-exo trig Heck-type cyclization is demonstrated.",

author = "Ghassan Albarghouti and Ramesh Kotikalapudi and David Lankri and Viviana Valerio and Dmitry Tsvelikhovsky",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2016.",

year = "2016",

doi = "10.1039/c5cc09923d",

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TY - JOUR

T1 - Cascade Pd(ii)-catalyzed Wacker lactonization-Heck reaction

T2 - Rapid assembly of spiranoid lactones

AU - Albarghouti, Ghassan

AU - Kotikalapudi, Ramesh

AU - Lankri, David

AU - Valerio, Viviana

AU - Tsvelikhovsky, Dmitry

PY - 2016

Y1 - 2016

N2 - An unprecedented Pd-catalyzed cascade Wacker-Heck lactonization-cyclization sequence is reported. The process provides a facile approach to bi- and tricyclic spiranoid lactones in good yields. The reaction shows general substrate scope and a broad functional group tolerability. In addition, a rare 4-exo trig Heck-type cyclization is demonstrated.

AB - An unprecedented Pd-catalyzed cascade Wacker-Heck lactonization-cyclization sequence is reported. The process provides a facile approach to bi- and tricyclic spiranoid lactones in good yields. The reaction shows general substrate scope and a broad functional group tolerability. In addition, a rare 4-exo trig Heck-type cyclization is demonstrated.

UR - http://www.scopus.com/inward/record.url?scp=84958052261&partnerID=8YFLogxK

U2 - 10.1039/c5cc09923d

DO - 10.1039/c5cc09923d

M3 - مقالة

SN - 1359-7345

VL - 52

SP - 3095

EP - 3098

JO - Chemical Communications

JF - Chemical Communications

IS - 15

ER -

Cascade Pd(ii)-catalyzed Wacker lactonization-Heck reaction: Rapid assembly of spiranoid lactones

Abstract

All Science Journal Classification (ASJC) codes

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