Cardiovascular aspects in Laron syndrome patients

Mickey Scheinowitz; Micha S. Feinberg; Michael Shechter; Zvi Laron; Rivka Kauli

doi:https://doi.org/10.1007/978-3-642-11183-9_33

Cardiovascular aspects in Laron syndrome patients

Mickey Scheinowitz, Micha S. Feinberg, Michael Shechter, Zvi Laron, Rivka Kauli

Department of Bio-Medical Engineering

Tel Aviv University

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The chapter describes the role of congenital insulin-like growth factor I (IGF-I) deficiency, such as in patients with Laron syndrome, on cardiac function, exercise capacity, endothelial function, and intimal thickening. Despite small cardiac dimensions, heart function is normal, exercise capacity is significantly reduced and endothelial function is similar to that of normal controls. Brachial artery diameter was significantly smaller than controls but with no differences in endothelial function measures. Intimal thickening in the common carotid and internal carotid arteries was slightly higher in LS compared with normal controls. The data highlight the risks for cardiovascular disease in IGF-I deficiency.

Original language	English
Title of host publication	Laron Syndrome - From Man to Mouse
Subtitle of host publication	Lessons from Clinical and Experimental Experience
Pages	293-305
Number of pages	13
DOIs	https://doi.org/10.1007/978-3-642-11183-9_33
State	Published - 2011

All Science Journal Classification (ASJC) codes

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://doi.org/10.1007/978-3-642-11183-9_33

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abstract = "The chapter describes the role of congenital insulin-like growth factor I (IGF-I) deficiency, such as in patients with Laron syndrome, on cardiac function, exercise capacity, endothelial function, and intimal thickening. Despite small cardiac dimensions, heart function is normal, exercise capacity is significantly reduced and endothelial function is similar to that of normal controls. Brachial artery diameter was significantly smaller than controls but with no differences in endothelial function measures. Intimal thickening in the common carotid and internal carotid arteries was slightly higher in LS compared with normal controls. The data highlight the risks for cardiovascular disease in IGF-I deficiency.",

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AB - The chapter describes the role of congenital insulin-like growth factor I (IGF-I) deficiency, such as in patients with Laron syndrome, on cardiac function, exercise capacity, endothelial function, and intimal thickening. Despite small cardiac dimensions, heart function is normal, exercise capacity is significantly reduced and endothelial function is similar to that of normal controls. Brachial artery diameter was significantly smaller than controls but with no differences in endothelial function measures. Intimal thickening in the common carotid and internal carotid arteries was slightly higher in LS compared with normal controls. The data highlight the risks for cardiovascular disease in IGF-I deficiency.

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BT - Laron Syndrome - From Man to Mouse

ER -

Cardiovascular aspects in Laron syndrome patients

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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