Cardiac KATP channel modulation by 16Hz magnetic fields - A theoretical study

Yuval Aharonovich; Mickey Scheinowitz; Sharon Zlochiver

doi:https://doi.org/10.1109/EMBC.2016.7590665

Cardiac KATP channel modulation by 16Hz magnetic fields - A theoretical study

Yuval Aharonovich, Mickey Scheinowitz, Sharon Zlochiver

Department of Bio-Medical Engineering

Tel Aviv University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Heart exposure to 16Hz magnetic fields (MFs) was shown to be cardio-protective for diseased hearts; still, the mechanism of this effect is unknown. We hypothesize that a possible one mechanism is an increased trans-membrane KATP channel open probability due to modulation of the degree of dissociation between K⁺ ions, having a resonance frequency of 16Hz, and the channel selectivity filter. The Fan-Makielski Markovian KATP channel model was adopted, and the MF bio-effect was manifested by modulating the open probability of the channel using the predictive MF bio-effect parameter based on Binhi's quantum mechanics model. The model was integrated in a ventricular single cell model and the MF effect on the calcium transients [Ca²⁺] was assessed. Periodic pacing (Cycle Length CL=1sec) was applied and a 16Hz or 32Hz MF was turned on at t=0 for 10min. MF exposure gradually decreased [Ca²⁺] due to KATP channel opening, more strongly at 16Hz. Additionally, a small negative diastolic shift was observed. These numerical results demonstrated similarity to published experimental data using similar 16Hz MF exposure. We conclude that 16Hz MF exposure increases the KATP channel open probability, lowering the cellular calcium load. Our model could be integrated in a tissue model to predict optimal MF parameters for future cardiac therapy devices.

Original language	English
Title of host publication	2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	161-164
Number of pages	4
ISBN (Electronic)	9781457702204
DOIs	https://doi.org/10.1109/EMBC.2016.7590665
State	Published - 13 Oct 2016
Event	38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 - Orlando, United States Duration: 16 Aug 2016 → 20 Aug 2016

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume	2016-October

Conference

Conference	38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
Country/Territory	United States
City	Orlando
Period	16/08/16 → 20/08/16

All Science Journal Classification (ASJC) codes

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

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https://doi.org/10.1109/EMBC.2016.7590665

Cite this

Aharonovich, Y., Scheinowitz, M., & Zlochiver, S. (2016). Cardiac KATP channel modulation by 16Hz magnetic fields - A theoretical study. In 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 (pp. 161-164). Article 7590665 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2016-October). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2016.7590665

Aharonovich, Yuval ; Scheinowitz, Mickey ; Zlochiver, Sharon. / Cardiac KATP channel modulation by 16Hz magnetic fields - A theoretical study. 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016. Institute of Electrical and Electronics Engineers Inc., 2016. pp. 161-164 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

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title = "Cardiac KATP channel modulation by 16Hz magnetic fields - A theoretical study",

abstract = "Heart exposure to 16Hz magnetic fields (MFs) was shown to be cardio-protective for diseased hearts; still, the mechanism of this effect is unknown. We hypothesize that a possible one mechanism is an increased trans-membrane KATP channel open probability due to modulation of the degree of dissociation between K+ ions, having a resonance frequency of 16Hz, and the channel selectivity filter. The Fan-Makielski Markovian KATP channel model was adopted, and the MF bio-effect was manifested by modulating the open probability of the channel using the predictive MF bio-effect parameter based on Binhi's quantum mechanics model. The model was integrated in a ventricular single cell model and the MF effect on the calcium transients [Ca2+] was assessed. Periodic pacing (Cycle Length CL=1sec) was applied and a 16Hz or 32Hz MF was turned on at t=0 for 10min. MF exposure gradually decreased [Ca2+] due to KATP channel opening, more strongly at 16Hz. Additionally, a small negative diastolic shift was observed. These numerical results demonstrated similarity to published experimental data using similar 16Hz MF exposure. We conclude that 16Hz MF exposure increases the KATP channel open probability, lowering the cellular calcium load. Our model could be integrated in a tissue model to predict optimal MF parameters for future cardiac therapy devices.",

author = "Yuval Aharonovich and Mickey Scheinowitz and Sharon Zlochiver",

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Aharonovich, Y, Scheinowitz, M & Zlochiver, S 2016, Cardiac KATP channel modulation by 16Hz magnetic fields - A theoretical study. in 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016., 7590665, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, vol. 2016-October, Institute of Electrical and Electronics Engineers Inc., pp. 161-164, 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016, Orlando, United States, 16/08/16. https://doi.org/10.1109/EMBC.2016.7590665

Cardiac KATP channel modulation by 16Hz magnetic fields - A theoretical study. / Aharonovich, Yuval; Scheinowitz, Mickey; Zlochiver, Sharon.
2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016. Institute of Electrical and Electronics Engineers Inc., 2016. p. 161-164 7590665 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2016-October).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Scheinowitz, Mickey

AU - Zlochiver, Sharon

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N2 - Heart exposure to 16Hz magnetic fields (MFs) was shown to be cardio-protective for diseased hearts; still, the mechanism of this effect is unknown. We hypothesize that a possible one mechanism is an increased trans-membrane KATP channel open probability due to modulation of the degree of dissociation between K+ ions, having a resonance frequency of 16Hz, and the channel selectivity filter. The Fan-Makielski Markovian KATP channel model was adopted, and the MF bio-effect was manifested by modulating the open probability of the channel using the predictive MF bio-effect parameter based on Binhi's quantum mechanics model. The model was integrated in a ventricular single cell model and the MF effect on the calcium transients [Ca2+] was assessed. Periodic pacing (Cycle Length CL=1sec) was applied and a 16Hz or 32Hz MF was turned on at t=0 for 10min. MF exposure gradually decreased [Ca2+] due to KATP channel opening, more strongly at 16Hz. Additionally, a small negative diastolic shift was observed. These numerical results demonstrated similarity to published experimental data using similar 16Hz MF exposure. We conclude that 16Hz MF exposure increases the KATP channel open probability, lowering the cellular calcium load. Our model could be integrated in a tissue model to predict optimal MF parameters for future cardiac therapy devices.

AB - Heart exposure to 16Hz magnetic fields (MFs) was shown to be cardio-protective for diseased hearts; still, the mechanism of this effect is unknown. We hypothesize that a possible one mechanism is an increased trans-membrane KATP channel open probability due to modulation of the degree of dissociation between K+ ions, having a resonance frequency of 16Hz, and the channel selectivity filter. The Fan-Makielski Markovian KATP channel model was adopted, and the MF bio-effect was manifested by modulating the open probability of the channel using the predictive MF bio-effect parameter based on Binhi's quantum mechanics model. The model was integrated in a ventricular single cell model and the MF effect on the calcium transients [Ca2+] was assessed. Periodic pacing (Cycle Length CL=1sec) was applied and a 16Hz or 32Hz MF was turned on at t=0 for 10min. MF exposure gradually decreased [Ca2+] due to KATP channel opening, more strongly at 16Hz. Additionally, a small negative diastolic shift was observed. These numerical results demonstrated similarity to published experimental data using similar 16Hz MF exposure. We conclude that 16Hz MF exposure increases the KATP channel open probability, lowering the cellular calcium load. Our model could be integrated in a tissue model to predict optimal MF parameters for future cardiac therapy devices.

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M3 - منشور من مؤتمر

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T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

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PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016

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ER -

Aharonovich Y, Scheinowitz M, Zlochiver S. Cardiac KATP channel modulation by 16Hz magnetic fields - A theoretical study. In 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016. Institute of Electrical and Electronics Engineers Inc. 2016. p. 161-164. 7590665. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). doi: https://doi.org/10.1109/EMBC.2016.7590665

Cardiac KATP channel modulation by 16Hz magnetic fields - A theoretical study

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