Boron nitride nanotube-based amphiphilic hybrid nanomaterials for superior encapsulation of hydrophobic cargos

Doaa Abu Saleh; Jukka Niskanen; Yanming Xue; Dmitri Golberg; Francoise M. Winnik; Alejandro Sosnik

doi:https://doi.org/10.1016/j.mtchem.2017.09.003

Boron nitride nanotube-based amphiphilic hybrid nanomaterials for superior encapsulation of hydrophobic cargos

Doaa Abu Saleh, Jukka Niskanen, Yanming Xue, Dmitri Golberg, Francoise M. Winnik, Alejandro Sosnik

Technion - Israel Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

We report an organic-inorganic hybrid core-shell nanomaterial obtained by conjugation of an amphiphilic monomethoxy-poly(ethylene glycol)-b-poly(epsilon-caprolactone) diblock copolymer to hydroxylated boron nitride nanotubes (BNNTs). The extent of copolymer grafting reached 64% w/w, an exceptionally high value. The hybrid materials exhibit excellent physical stability in water and an outstanding loading capacity (31.3% w/w) for curcumin, a hydrophobic drug. Moreover, they present good compatibility with the Caco2 cell line, a model of intestinal epithelium. Our findings demonstrate the potential of multifunctional hybrid BNNTs to serve as a platform for complex amphiphilic nanoparticle architectures with improved features.

Original language	English
Pages (from-to)	45-50
Number of pages	6
Journal	Materials Today Chemistry
Volume	6
DOIs	https://doi.org/10.1016/j.mtchem.2017.09.003
State	Published - Dec 2017

Keywords

Boron nitride nanotubes
Core-shell amphiphilic hybrid nanomaterials
Curcumin
Drug encapsulation
Polymeric micelles

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Biomaterials
Polymers and Plastics
Colloid and Surface Chemistry
Materials Chemistry

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https://doi.org/10.1016/j.mtchem.2017.09.003

Cite this

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title = "Boron nitride nanotube-based amphiphilic hybrid nanomaterials for superior encapsulation of hydrophobic cargos",

abstract = "We report an organic-inorganic hybrid core-shell nanomaterial obtained by conjugation of an amphiphilic monomethoxy-poly(ethylene glycol)-b-poly(epsilon-caprolactone) diblock copolymer to hydroxylated boron nitride nanotubes (BNNTs). The extent of copolymer grafting reached 64% w/w, an exceptionally high value. The hybrid materials exhibit excellent physical stability in water and an outstanding loading capacity (31.3% w/w) for curcumin, a hydrophobic drug. Moreover, they present good compatibility with the Caco2 cell line, a model of intestinal epithelium. Our findings demonstrate the potential of multifunctional hybrid BNNTs to serve as a platform for complex amphiphilic nanoparticle architectures with improved features.",

keywords = "Boron nitride nanotubes, Core-shell amphiphilic hybrid nanomaterials, Curcumin, Drug encapsulation, Polymeric micelles",

author = "{Abu Saleh}, Doaa and Jukka Niskanen and Yanming Xue and Dmitri Golberg and Winnik, {Francoise M.} and Alejandro Sosnik",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

year = "2017",

month = dec,

doi = "https://doi.org/10.1016/j.mtchem.2017.09.003",

language = "الإنجليزيّة",

volume = "6",

pages = "45--50",

journal = "Materials Today Chemistry",

issn = "2468-5194",

publisher = "Elsevier Ltd.",

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TY - JOUR

T1 - Boron nitride nanotube-based amphiphilic hybrid nanomaterials for superior encapsulation of hydrophobic cargos

AU - Abu Saleh, Doaa

AU - Niskanen, Jukka

AU - Xue, Yanming

AU - Golberg, Dmitri

AU - Winnik, Francoise M.

AU - Sosnik, Alejandro

PY - 2017/12

Y1 - 2017/12

N2 - We report an organic-inorganic hybrid core-shell nanomaterial obtained by conjugation of an amphiphilic monomethoxy-poly(ethylene glycol)-b-poly(epsilon-caprolactone) diblock copolymer to hydroxylated boron nitride nanotubes (BNNTs). The extent of copolymer grafting reached 64% w/w, an exceptionally high value. The hybrid materials exhibit excellent physical stability in water and an outstanding loading capacity (31.3% w/w) for curcumin, a hydrophobic drug. Moreover, they present good compatibility with the Caco2 cell line, a model of intestinal epithelium. Our findings demonstrate the potential of multifunctional hybrid BNNTs to serve as a platform for complex amphiphilic nanoparticle architectures with improved features.

AB - We report an organic-inorganic hybrid core-shell nanomaterial obtained by conjugation of an amphiphilic monomethoxy-poly(ethylene glycol)-b-poly(epsilon-caprolactone) diblock copolymer to hydroxylated boron nitride nanotubes (BNNTs). The extent of copolymer grafting reached 64% w/w, an exceptionally high value. The hybrid materials exhibit excellent physical stability in water and an outstanding loading capacity (31.3% w/w) for curcumin, a hydrophobic drug. Moreover, they present good compatibility with the Caco2 cell line, a model of intestinal epithelium. Our findings demonstrate the potential of multifunctional hybrid BNNTs to serve as a platform for complex amphiphilic nanoparticle architectures with improved features.

KW - Boron nitride nanotubes

KW - Core-shell amphiphilic hybrid nanomaterials

KW - Curcumin

KW - Drug encapsulation

KW - Polymeric micelles

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U2 - https://doi.org/10.1016/j.mtchem.2017.09.003

DO - https://doi.org/10.1016/j.mtchem.2017.09.003

M3 - مقالة

SN - 2468-5194

VL - 6

SP - 45

EP - 50

JO - Materials Today Chemistry

JF - Materials Today Chemistry

ER -

Boron nitride nanotube-based amphiphilic hybrid nanomaterials for superior encapsulation of hydrophobic cargos

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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