TY - JOUR
T1 - Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”)
AU - Foessl, Ines
AU - Bassett, J. H.Duncan
AU - Bjørnerem, Åshild
AU - Busse, Björn
AU - Calado, Ângelo
AU - Chavassieux, Pascale
AU - Christou, Maria
AU - Douni, Eleni
AU - Fiedler, Imke A.K.
AU - Fonseca, João Eurico
AU - Hassler, Eva
AU - Högler, Wolfgang
AU - Kague, Erika
AU - Karasik, David
AU - Khashayar, Patricia
AU - Langdahl, Bente L.
AU - Leitch, Victoria D.
AU - Lopes, Philippe
AU - Markozannes, Georgios
AU - McGuigan, Fiona E.A.
AU - Medina-Gomez, Carolina
AU - Ntzani, Evangelia
AU - Oei, Ling
AU - Ohlsson, Claes
AU - Szulc, Pawel
AU - Tobias, Jonathan H.
AU - Trajanoska, Katerina
AU - Tuzun, Şansın
AU - Valjevac, Amina
AU - van Rietbergen, Bert
AU - Williams, Graham R.
AU - Zekic, Tatjana
AU - Rivadeneira, Fernando
AU - Obermayer-Pietsch, Barbara
N1 - Publisher Copyright: Copyright © 2021 Foessl, Bassett, Bjørnerem, Busse, Calado, Chavassieux, Christou, Douni, Fiedler, Fonseca, Hassler, Högler, Kague, Karasik, Khashayar, Langdahl, Leitch, Lopes, Markozannes, McGuigan, Medina-Gomez, Ntzani, Oei, Ohlsson, Szulc, Tobias, Trajanoska, Tuzun, Valjevac, van Rietbergen, Williams, Zekic, Rivadeneira and Obermayer-Pietsch.
PY - 2021/12/1
Y1 - 2021/12/1
N2 - A synoptic overview of scientific methods applied in bone and associated research fields across species has yet to be published. Experts from the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal Traits translational Network”) Working Group 2 present an overview of the routine techniques as well as clinical and research approaches employed to characterize bone phenotypes in humans and selected animal models (mice and zebrafish) of health and disease. The goal is consolidation of knowledge and a map for future research. This expert paper provides a comprehensive overview of state-of-the-art technologies to investigate bone properties in humans and animals – including their strengths and weaknesses. New research methodologies are outlined and future strategies are discussed to combine phenotypic with rapidly developing –omics data in order to advance musculoskeletal research and move towards “personalised medicine”.
AB - A synoptic overview of scientific methods applied in bone and associated research fields across species has yet to be published. Experts from the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal Traits translational Network”) Working Group 2 present an overview of the routine techniques as well as clinical and research approaches employed to characterize bone phenotypes in humans and selected animal models (mice and zebrafish) of health and disease. The goal is consolidation of knowledge and a map for future research. This expert paper provides a comprehensive overview of state-of-the-art technologies to investigate bone properties in humans and animals – including their strengths and weaknesses. New research methodologies are outlined and future strategies are discussed to combine phenotypic with rapidly developing –omics data in order to advance musculoskeletal research and move towards “personalised medicine”.
KW - COST
KW - GEMSTONE
KW - animal models
KW - bone and skeletal diseases
KW - imaging
KW - phenotyping
UR - http://www.scopus.com/inward/record.url?scp=85121349738&partnerID=8YFLogxK
U2 - https://doi.org/10.3389/fendo.2021.720728
DO - https://doi.org/10.3389/fendo.2021.720728
M3 - مقالة مرجعية
C2 - 34925226
SN - 1664-2392
VL - 12
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
M1 - 720728
ER -
