Bombarding cancer: Biolistic delivery of therapeutics using porous si carriers

Neta Zilony; Adi Tzur-Balter; Ester Segal; Orit Shefi

doi:10.1038/srep02499

Bombarding cancer: Biolistic delivery of therapeutics using porous si carriers

Neta Zilony, Adi Tzur-Balter, Ester Segal, Orit Shefi

Bar-Ilan University, Technion - Israel Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

A new paradigm for an effective delivery of therapeutics into cancer cells is presented. Degradable porous silicon carriers, which are tailored to carry and release a model anti-cancer drug, are biolistically bombarded into in-vitro cancerous targets. We demonstrate the ability to launch these highly porous microparticles by a pneumatic capillary gene gun, which is conventionally used to deliver cargos by heavy metal carriers. By optimizing the gun parameters e.g., the accelerating gas pressure, we have successfully delivered the porous carriers, to reach deep targets and to cross a skin barrier in a highly spatial resolution. Our study reveals significant cytotoxicity towards the target human breast carcinoma cells following the delivery of drug-loaded carriers, while administrating empty particles results in no effect on cell viability. The unique combination of biolistics with the temporal control of payload release from porous carriers presents a powerful and non-conventional platform for designing new therapeutic strategies.

Original language	English
Article number	2499
Journal	Scientific Reports
Volume	3
DOIs	https://doi.org/10.1038/srep02499
State	Published - 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

General

Access to Document

10.1038/srep02499

Cite this

@article{5adde96033d04f139a50d22f39a41d66,

title = "Bombarding cancer: Biolistic delivery of therapeutics using porous si carriers",

abstract = "A new paradigm for an effective delivery of therapeutics into cancer cells is presented. Degradable porous silicon carriers, which are tailored to carry and release a model anti-cancer drug, are biolistically bombarded into in-vitro cancerous targets. We demonstrate the ability to launch these highly porous microparticles by a pneumatic capillary gene gun, which is conventionally used to deliver cargos by heavy metal carriers. By optimizing the gun parameters e.g., the accelerating gas pressure, we have successfully delivered the porous carriers, to reach deep targets and to cross a skin barrier in a highly spatial resolution. Our study reveals significant cytotoxicity towards the target human breast carcinoma cells following the delivery of drug-loaded carriers, while administrating empty particles results in no effect on cell viability. The unique combination of biolistics with the temporal control of payload release from porous carriers presents a powerful and non-conventional platform for designing new therapeutic strategies.",

author = "Neta Zilony and Adi Tzur-Balter and Ester Segal and Orit Shefi",

note = "Funding Information: This work was partially supported by the NEVET Grant administered by the Russell Berrie Nanotechnology Institute (RBNI) and the Bar-Ilan Institute of Nanotechnology \& Advanced Materials (BINA). O.S. acknowledges the EU-FP7 People IRG Grants 239482. E.S. acknowledges the support of the Lorry I. Lokey Interdisciplinary Center for Life Sciences and Engineering. N.Z. gratefully acknowledges the BINA Scholarship for Outstanding Graduate Students. A.T.B. gratefully acknowledges the RBNI Scholarship for Outstanding Graduate Students. The authors thank Prof. Alex Groisman from the University of California, San Diego, for his support in the setting of the biolistic setups.",

year = "2013",

doi = "10.1038/srep02499",

language = "الإنجليزيّة",

volume = "3",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Bombarding cancer

T2 - Biolistic delivery of therapeutics using porous si carriers

AU - Zilony, Neta

AU - Tzur-Balter, Adi

AU - Segal, Ester

AU - Shefi, Orit

N1 - Funding Information: This work was partially supported by the NEVET Grant administered by the Russell Berrie Nanotechnology Institute (RBNI) and the Bar-Ilan Institute of Nanotechnology & Advanced Materials (BINA). O.S. acknowledges the EU-FP7 People IRG Grants 239482. E.S. acknowledges the support of the Lorry I. Lokey Interdisciplinary Center for Life Sciences and Engineering. N.Z. gratefully acknowledges the BINA Scholarship for Outstanding Graduate Students. A.T.B. gratefully acknowledges the RBNI Scholarship for Outstanding Graduate Students. The authors thank Prof. Alex Groisman from the University of California, San Diego, for his support in the setting of the biolistic setups.

PY - 2013

Y1 - 2013

N2 - A new paradigm for an effective delivery of therapeutics into cancer cells is presented. Degradable porous silicon carriers, which are tailored to carry and release a model anti-cancer drug, are biolistically bombarded into in-vitro cancerous targets. We demonstrate the ability to launch these highly porous microparticles by a pneumatic capillary gene gun, which is conventionally used to deliver cargos by heavy metal carriers. By optimizing the gun parameters e.g., the accelerating gas pressure, we have successfully delivered the porous carriers, to reach deep targets and to cross a skin barrier in a highly spatial resolution. Our study reveals significant cytotoxicity towards the target human breast carcinoma cells following the delivery of drug-loaded carriers, while administrating empty particles results in no effect on cell viability. The unique combination of biolistics with the temporal control of payload release from porous carriers presents a powerful and non-conventional platform for designing new therapeutic strategies.

AB - A new paradigm for an effective delivery of therapeutics into cancer cells is presented. Degradable porous silicon carriers, which are tailored to carry and release a model anti-cancer drug, are biolistically bombarded into in-vitro cancerous targets. We demonstrate the ability to launch these highly porous microparticles by a pneumatic capillary gene gun, which is conventionally used to deliver cargos by heavy metal carriers. By optimizing the gun parameters e.g., the accelerating gas pressure, we have successfully delivered the porous carriers, to reach deep targets and to cross a skin barrier in a highly spatial resolution. Our study reveals significant cytotoxicity towards the target human breast carcinoma cells following the delivery of drug-loaded carriers, while administrating empty particles results in no effect on cell viability. The unique combination of biolistics with the temporal control of payload release from porous carriers presents a powerful and non-conventional platform for designing new therapeutic strategies.

UR - http://www.scopus.com/inward/record.url?scp=84883306486&partnerID=8YFLogxK

U2 - 10.1038/srep02499

DO - 10.1038/srep02499

M3 - مقالة

C2 - 23975675

SN - 2045-2322

VL - 3

JO - Scientific Reports

JF - Scientific Reports

M1 - 2499

ER -

Bombarding cancer: Biolistic delivery of therapeutics using porous si carriers

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this