Biosensor and method of detection of a DNA sequence

Serge A Cosnier; Robert S Marks; Elena R Ionescu

Biosensor and method of detection of a DNA sequence

Serge A Cosnier (Inventor)
, Robert S Marks (Inventor)
, Elena R Ionescu (Inventor)

Department of Biotechnology Engineering

Ben-Gurion University of the Negev

Research output: Patent

Abstract

The invention relates biosensor comprising a conductive or
semi-conductive Support and an intercalator polymer, wherein the intercalator polymer comprises monomer units of formula (I) wherein P is an electropolymerizable moiety selected among the group consisting in pyrrole, acetylene, phenol, aniline, thiophene, carbazole and azulene; Sp is a spacer, and Im is an intercalator.
The invention also relates to a method for the detection of a
DNA sequence with the biosensor, comprising the steps of hybridizing the DNA sequence with a DNA probe for forming a dsDNA incubating the biosensor with the dsDNA for anchoring the dsDNA to the intercalator detecting the quantity of dsDNA on the biosensor.

Original language	American English
Patent number	US 7,947,836 B2
State	Published - 1 May 2011

Cite this

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title = "Biosensor and method of detection of a DNA sequence",

abstract = "The invention relates biosensor comprising a conductive or semi-conductive Support and an intercalator polymer, wherein the intercalator polymer comprises monomer units of formula (I) wherein P is an electropolymerizable moiety selected among the group consisting in pyrrole, acetylene, phenol, aniline, thiophene, carbazole and azulene; Sp is a spacer, and Im is an intercalator. The invention also relates to a method for the detection of a DNA sequence with the biosensor, comprising the steps of hybridizing the DNA sequence with a DNA probe for forming a dsDNA incubating the biosensor with the dsDNA for anchoring the dsDNA to the intercalator detecting the quantity of dsDNA on the biosensor. ",

author = "Cosnier, \{Serge A\} and Marks, \{Robert S\} and Ionescu, \{Elena R\}",

note = "US Patent 7,947,836; US 7,947,836 B2",

year = "2011",

month = may,

day = "1",

language = "American English",

type = "Patent",

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TY - PAT

T1 - Biosensor and method of detection of a DNA sequence

AU - Cosnier, Serge A

AU - Marks, Robert S

AU - Ionescu, Elena R

N1 - US Patent 7,947,836

PY - 2011/5/1

Y1 - 2011/5/1

N2 - The invention relates biosensor comprising a conductive or semi-conductive Support and an intercalator polymer, wherein the intercalator polymer comprises monomer units of formula (I) wherein P is an electropolymerizable moiety selected among the group consisting in pyrrole, acetylene, phenol, aniline, thiophene, carbazole and azulene; Sp is a spacer, and Im is an intercalator. The invention also relates to a method for the detection of a DNA sequence with the biosensor, comprising the steps of hybridizing the DNA sequence with a DNA probe for forming a dsDNA incubating the biosensor with the dsDNA for anchoring the dsDNA to the intercalator detecting the quantity of dsDNA on the biosensor.

AB - The invention relates biosensor comprising a conductive or semi-conductive Support and an intercalator polymer, wherein the intercalator polymer comprises monomer units of formula (I) wherein P is an electropolymerizable moiety selected among the group consisting in pyrrole, acetylene, phenol, aniline, thiophene, carbazole and azulene; Sp is a spacer, and Im is an intercalator. The invention also relates to a method for the detection of a DNA sequence with the biosensor, comprising the steps of hybridizing the DNA sequence with a DNA probe for forming a dsDNA incubating the biosensor with the dsDNA for anchoring the dsDNA to the intercalator detecting the quantity of dsDNA on the biosensor.

M3 - Patent

M1 - US 7,947,836 B2

ER -

Biosensor and method of detection of a DNA sequence

Abstract

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