Biomimetic Glyconanoparticle Nanoghost Vaccine Based on Red Blood Cells

Nofar Israel; Shani Leviatan Ben-Arye; Andrea Perota; Cesare Galli; Vered Padler-Karavani

doi:10.1007/978-1-0716-4542-0_11

Biomimetic Glyconanoparticle Nanoghost Vaccine Based on Red Blood Cells

Nofar Israel, Shani Leviatan Ben-Arye, Andrea Perota, Cesare Galli, Vered Padler-Karavani

The Shmunis School of Biomedicine and Cancer Research

Tel Aviv University

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Cancer vaccine is an active immunotherapy approach that aims to stimulate the host’s immune responses toward specific targets on cancer cells, to direct their killing. Cancer cells commonly express aberrant cell surface glycosylation that support their immune evasion. Therefore, cancer glycosylation could be used as an efficient target for therapy. Lipid-based glyconanoparticles that express cancer glycosylation could mimic cancer cells and be used as therapeutic cancer vaccines. Here, we describe generation of biomimetic glyconanoparticles cancer vaccine based on porcine red blood cells that express cancer glycosylation containing the dietary nonhuman sialic acid N-glycolylneuraminic acid (Neu5Gc).

Original language	English
Title of host publication	Methods in Molecular Biology
Pages	143-156
Number of pages	14
DOIs	https://doi.org/10.1007/978-1-0716-4542-0_11
State	Published - 2025

Publication series

Name	Methods in Molecular Biology
Volume	2926

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Biomimetic
Cancer vaccine
Glycan microarray
Glyconanoparticle
N-glycolylneuraminic acid (Neu5Gc)
Sialic acid

All Science Journal Classification (ASJC) codes

Molecular Biology
Genetics

Access to Document

10.1007/978-1-0716-4542-0_11

Cite this

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abstract = "Cancer vaccine is an active immunotherapy approach that aims to stimulate the host{\textquoteright}s immune responses toward specific targets on cancer cells, to direct their killing. Cancer cells commonly express aberrant cell surface glycosylation that support their immune evasion. Therefore, cancer glycosylation could be used as an efficient target for therapy. Lipid-based glyconanoparticles that express cancer glycosylation could mimic cancer cells and be used as therapeutic cancer vaccines. Here, we describe generation of biomimetic glyconanoparticles cancer vaccine based on porcine red blood cells that express cancer glycosylation containing the dietary nonhuman sialic acid N-glycolylneuraminic acid (Neu5Gc).",

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author = "Nofar Israel and \{Leviatan Ben-Arye\}, Shani and Andrea Perota and Cesare Galli and Vered Padler-Karavani",

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doi = "10.1007/978-1-0716-4542-0\_11",

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AU - Israel, Nofar

AU - Leviatan Ben-Arye, Shani

AU - Perota, Andrea

AU - Galli, Cesare

AU - Padler-Karavani, Vered

N1 - Publisher Copyright: © The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2025.

PY - 2025

Y1 - 2025

N2 - Cancer vaccine is an active immunotherapy approach that aims to stimulate the host’s immune responses toward specific targets on cancer cells, to direct their killing. Cancer cells commonly express aberrant cell surface glycosylation that support their immune evasion. Therefore, cancer glycosylation could be used as an efficient target for therapy. Lipid-based glyconanoparticles that express cancer glycosylation could mimic cancer cells and be used as therapeutic cancer vaccines. Here, we describe generation of biomimetic glyconanoparticles cancer vaccine based on porcine red blood cells that express cancer glycosylation containing the dietary nonhuman sialic acid N-glycolylneuraminic acid (Neu5Gc).

AB - Cancer vaccine is an active immunotherapy approach that aims to stimulate the host’s immune responses toward specific targets on cancer cells, to direct their killing. Cancer cells commonly express aberrant cell surface glycosylation that support their immune evasion. Therefore, cancer glycosylation could be used as an efficient target for therapy. Lipid-based glyconanoparticles that express cancer glycosylation could mimic cancer cells and be used as therapeutic cancer vaccines. Here, we describe generation of biomimetic glyconanoparticles cancer vaccine based on porcine red blood cells that express cancer glycosylation containing the dietary nonhuman sialic acid N-glycolylneuraminic acid (Neu5Gc).

KW - Biomimetic

KW - Cancer vaccine

KW - Glycan microarray

KW - Glyconanoparticle

KW - N-glycolylneuraminic acid (Neu5Gc)

KW - Sialic acid

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Biomimetic Glyconanoparticle Nanoghost Vaccine Based on Red Blood Cells

Abstract

Publication series

UN SDGs

Keywords

All Science Journal Classification (ASJC) codes

Access to Document

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