Biomimetic Glyconanoparticle Nanoghost Vaccine Based on Red Blood Cells

Nofar Israel, Shani Leviatan Ben-Arye, Andrea Perota, Cesare Galli, Vered Padler-Karavani

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Cancer vaccine is an active immunotherapy approach that aims to stimulate the host’s immune responses toward specific targets on cancer cells, to direct their killing. Cancer cells commonly express aberrant cell surface glycosylation that support their immune evasion. Therefore, cancer glycosylation could be used as an efficient target for therapy. Lipid-based glyconanoparticles that express cancer glycosylation could mimic cancer cells and be used as therapeutic cancer vaccines. Here, we describe generation of biomimetic glyconanoparticles cancer vaccine based on porcine red blood cells that express cancer glycosylation containing the dietary nonhuman sialic acid N-glycolylneuraminic acid (Neu5Gc).

Original languageEnglish
Title of host publicationMethods in Molecular Biology
Pages143-156
Number of pages14
DOIs
StatePublished - 2025

Publication series

NameMethods in Molecular Biology
Volume2926

Keywords

  • Biomimetic
  • Cancer vaccine
  • Glycan microarray
  • Glyconanoparticle
  • N-glycolylneuraminic acid (Neu5Gc)
  • Sialic acid

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics

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