Biomechanical aspects of skin aging-the risk of skin breakdown under shear loading increases with age

Daniel Garcia-Martinez, Maria Fabiola Leyva-Mendivil, Amit Gefen, Georges Limbert

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

In skin, the living epidermis is connected to the underlying dermis through a basement membrane, the dermal-epidermal junction (DEJ), which features a three-dimensional interlocking wavy topography. The DEJ flattens with age while there is also an increased probability of skin tears with age. Moreover, in situations where patients with a fragile skin, especially geriatric, malnourished, or incontinent patients, are being moved or are moving in bed or on a chair, clinical evidence indicates that the skin may break down. It is therefore intriguing to question whether the convoluted nature of the DEJ may play an important role in the ability of skin to resist mechanical shear loads. Here, this clinically relevant topic is explored using an idealized, yet sophisticated, parametric multilayer finite element model of the human skin as it ages. The flattening of the DEJ with age was shown to induce significantly higher and more uniformly concentrated normal and shear stresses at the DEJ, which are correlated with higher likelihood of material damage. This study therefore suggests that the risk of skin breakdown under shear loading increases with age.

Original languageEnglish
Title of host publicationInnovations and Emerging Technologies in Wound Care
PublisherElsevier
Pages309-335
Number of pages27
ISBN (Electronic)9780128150283
ISBN (Print)9780128150290
DOIs
StatePublished - 1 Jan 2019

Keywords

  • Ageing
  • Dermal-epidermal junction
  • Finite element
  • Mechanical properties
  • Modeling
  • Shear
  • Skin
  • Strain
  • Stress
  • Tears
  • Ulcers

All Science Journal Classification (ASJC) codes

  • General Biochemistry,Genetics and Molecular Biology

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